Publications
This section provides links to selected publications, published both online and in print.
Publications are listed in chronological order, the first being the most recent.
A consideration of the social dimensions and implications of neuroimaging research in global health, as related to the theory-ladened and theory-generating aspects of technology.
Pickersgill M.
A Differential Effect of Lovastatin versus Simvastatin in Neurodevelopmental Disorders.
Muscas M, Seo SS, Louros SR, Osterweil EK.
A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage.
Bernal J, Valdés-Hernández MDC, Escudero J, Heye AK, Sakka E, Armitage PA, Makin S, Touyz RM, Wardlaw JM, Thrippleton MJ.
Alexithymia and Autistic Traits as Contributing Factors to Empathy Difficulties in Preadolescent Children.
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.
Perkins EM, Burr K, Banerjee P, Mehta AR, Dando O, Selvaraj BT, Suminaite D, Nanda J, Henstridge CM, Gillingwater TH, Hardingham GE, Wyllie DJA, Chandran S, Livesey MR.
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations.
Patkar OL, Caruso M, Teakle N, Keshvari S, Bush SJ, Pridans C, Belmer A, Summers KM, Irvine KM, Hume DA.
Are you tuned in? The challenges of seizure identification in children with intellectual disability - A potential for video-based care-pathway.
Hutchison M, Buxton G, Brand C, McLellan A, Shetty J.
Assessment of Outliers and Detection of Artifactual Network Segments Using Univariate and Multivariate Dispersion Entropy on Physiological Signals.
Kafantaris E, Piper I, Lo TM, Escudero J.
Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
Children's understanding of epilepsy: A qualitative study.
Harden J, Black R, Pickersgill M, Shetty J, McLellan A, Brand C, Small M, McDonnell J, Clarke L, Chin RF.
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
Current molecular approaches to investigate pre-synaptic dysfunction.
Harper CB, Smillie KJ.
Deep Learning of resting-state electroencephalogram signals for 3-class classification of Alzheimer's Disease, Mild Cognitive Impairment and Healthy Ageing.
Huggins CJ, Escudero J, Parra MA, Scally B, Anghinah R, Vitória Lacerda de Araújo A, Basile LF, Abasolo D.
Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.
Lodi L, Melki I, Bondet V, Seabra L, Rice GI, Carter E, Lepelley A, Martin-Niclós MJ, Al Adba B, Bader-Meunier B, Barth M, Blauwblomme T, Bodemer C, Boespflug-Tanguy O, Dale RC, Desguerre I, Ducrocq C, Dulieu F, Dumaine C, Ellul P, Hadchouel A, Hentgen V, Hié M, Hully M, Jeziorski E, Lévy R, Mochel F, Orcesi S, Passemard S, Pouletty M, Quartier P, Renaldo F, Seidl R, Shetty J, Neven B, Blanche S, Duffy D, Crow YJ, Frémond ML.
Epidemiology and outcome of status epilepticus in children: a Scottish population cohort study.
Mitchell C, Chatterton Dickson L, Ramsay A, Mesalles-Naranjo O, Leonard P, Brand C, Mclellan A, Shetty J.
Glutamate and functional connectivity - support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders.
Siegel-Ramsay JE, Romaniuk L, Whalley HC, Roberts N, Branigan H, Stanfield AC, Lawrie SM, Dauvermann MR.
Hierarchical Complexity of the Macro-Scale Neonatal Brain.
Blesa M, Galdi P, Cox SR, Sullivan G, Stoye DQ, Lamb GJ, Quigley AJ, Thrippleton MJ, Escudero J, Bastin ME, Smith KM, Boardman JP.
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.
Bertelsen N, Landi I, Bethlehem RAI, Seidlitz J, Busuoli EM, Mandelli V, Satta E, Trakoshis S, Auyeung B, Kundu P, Loth E, Dumas G, Baumeister S, Beckmann CF, Bölte S, Bourgeron T, Charman T, Durston S, Ecker C, Holt RJ, Johnson MH, Jones EJH, Mason L, Meyer-Lindenberg A, Moessnang C, Oldehinkel M, Persico AM, Tillmann J, Williams SCR, Spooren W, Murphy DGM, Buitelaar JK; EU-AIMS LEAP group, Baron-Cohen S, Lai MC, Lombardo MV.
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
Horner AE, Norris RH, McLaren-Jones R, Alexander L, Komiyama NH, Grant SGN, Nithianantharajah J, Kopanitsa MV.
Links between perinatal risk factors and maternal psychological distress: A network analysis.
Speyer LG, Hall HA, Ushakova A, Murray AL, Luciano M, Auyeung B.
Longitudinal effects of breast feeding on parent-reported child behaviour.
Speyer LG, Hall HA, Ushakova A, Murray AL, Luciano M, Auyeung B.
Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.
Babiloni C, Arakaki X, Azami H, Bennys K, Blinowska K, Bonanni L, Bujan A, Carrillo MC, Cichocki A, de Frutos-Lucas J, Del Percio C, Dubois B, Edelmayer R, Egan G, Epelbaum S, Escudero J, Evans A, Farina F, Fargo K, Fernández A, Ferri R, Frisoni G, Hampel H, Harrington MG, Jelic V, Jeong J, Jiang Y, Kaminski M, Kavcic V, Kilborn K, Kumar S, Lam A, Lim L, Lizio R, Lopez D, Lopez S, Lucey B, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Noce G, Olichney J, Onofrj M, Osorio R, Parra-Rodriguez M, Rajji T, Ritter P, Soricelli A, Stocchi F, Tarnanas I, Taylor JP, Teipel S, Tucci F, Valdes-Sosa M, Valdes-Sosa P, Weiergräber M, Yener G, Guntekin B.
Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.
Hristova K, Martinez-Gonzalez C, Watson TC, Codadu NK, Hashemi K, Kind PC, Nolan MF, Gonzalez-Sulser A.
Modelling epilepsy in the mouse: challenges and solutions.
Marshall GF, Gonzalez-Sulser A, Abbott CM.
Monitoring Activity-Dependent Bulk Endocytosis in Primary Neuronal Culture Using Large Fluorescent Dextrans.
Cousin MA, Smillie KJ.
NMDA receptor function in inhibitory neurons.
Booker SA, Wyllie DJA.
Pathogenic variants causing ABL1 malformation syndrome cluster in a myristoyl-binding pocket and increase tyrosine kinase activity.
Blakes AJM, Gaul E, Lam W, Shannon N, Knapp KM, Bicknell LS, Jackson MR, Wade EM, Robertson S, White SM, Heller R, Chase A, Baralle D, Douglas AGL.
Pilot project of psychological services integrated into a pediatric epilepsy clinic: Psychology Adding Value - Epilepsy Screening (PAVES).
George C, Felix SA, McLellan A, Shetty J, Middleton J, Chin RF, Poveda B, Brand C, Small M, Verity K.
Preface to the Special Issue "Presynaptic Dysfunction and Disease".
Smillie KJ, Cousin MA, Gordon SL.
Prenatal Maternal Infections and Children's Neurodevelopment in the UK Millennium Cohort Study: A Focus on ASD and ADHD.
Hall HA, Speyer LG, Murray AL, Auyeung B.
Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle.
Bonnycastle K, Davenport EC, Cousin MA.
Selective vulnerability of inhibitory networks in multiple sclerosis.
Zoupi L, Booker SA, Eigel D, Werner C, Kind PC, Spires-Jones TL, Newland B, Williams AC.
Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells.
Cao H, Neerincx A, de Bono B, Lakner U, Huntington C, Elvin J, Gudgin E, Pridans C, Vickers MA, Huntly B, Trowsdale J, Barrow AD.
Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review.
Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L.
Synaptophysin controls synaptobrevin-II retrieval via a cryptic C-terminal interaction site.
Harper CB, Blumrich EM, Cousin MA.
The contribution of X-linked coding variation to severe developmental disorders.
Martin HC, Gardner EJ, Samocha KE, Kaplanis J, Akawi N, Sifrim A, Eberhardt RY, Tavares ALT, Neville MDC, Niemi MEK, Gallone G, McRae J; Deciphering Developmental Disorders Study, Wright CF, FitzPatrick DR, Firth HV, Hurles ME.
The Mononuclear Phagocyte System of the Rat.
Hume DA, Caruso M, Keshvari S, Patkar OL, Sehgal A, Bush SJ, Summers KM, Pridans C, Irvine KM.
Thesis write-up and manuscript preparation: related but distinct tasks.
Wyllie DJA.
Transcriptomic Analysis of Rat Macrophages.
Pridans C, Irvine KM, Davis GM, Lefevre L, Bush SJ, Hume DA.
A brainwide atlas of synapses across the mouse life span.
Cizeron M, Qiu Z, Koniaris B, Gokhale R, Komiyama NH, Fransén E, Grant SGN.
A clinical evaluation of a novel algorithm in the reliable detection of epileptic seizures.
Brotherstone R, McLellan A, Graham C, Fisher K.
A nationwide, retrospective, data-linkage, cohort study of epilepsy and incident dementia.
Schnier C, Duncan S, Wilkinson T, Mbizvo GK, Chin RFM.
A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB.
A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System.
Grabert K, Sehgal A, Irvine KM, Wollscheid-Lengeling E, Ozdemir DD, Stables J, Luke GA, Ryan MD, Adamson A, Humphreys NE, Sandrock CJ, Rojo R, Verkasalo VA, Mueller W, Hohenstein P, Pettit AR, Pridans C, Hume DA.
Accuracy of identifying incident stroke cases from linked health care data in UK Biobank.
Rannikmäe K, Ngoh K, Bush K, Al-Shahi Salman R, Doubal F, Flaig R, Henshall DE, Hutchison A, Nolan J, Osborne S, Samarasekera N, Schnier C, Whiteley W, Wilkinson T, Wilson K, Woodfield R, Zhang Q, Allen N, Sudlow CLM.
Adults with epilepsy appear to differ from children in regard to daytime sleepiness.
Urquhart DS, Hill EA, Hill LE, Carruthers E, McLellan AE, Chin R, Shetty J.
An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking.
Harper CB, Small C, Davenport EC, Low DW, Smillie KJ, Martínez-Mármol R, Meunier FA, Cousin MA.
Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease.
Bernal J, Valdés-Hernández MDC, Escudero J, Viksne L, Heye AK, Armitage PA, Makin S, Touyz RM, Wardlaw JM.
Analysis of the impact of CSF-1 administration in adult rats using a novel Csf1r-mApple reporter gene.
Irvine KM, Caruso M, Cestari MF, Davis GM, Keshvari S, Sehgal A, Pridans C, Hume DA.
Augmentation of Dispersion Entropy for Handling Missing and Outlier Samples in Physiological Signal Monitoring.
Kafantaris E, Piper I, Lo TM, Escudero J.
Bilingualism in autism: Language learning profiles and social experiences.
Digard BG, Sorace A, Stanfield A, Fletcher-Watson S.
Categorical and Dimensional Approaches to Examining the Joint Effect of Autism and Schizotypal Personality Disorder on Sustained Attention.
Abu-Akel A, Philip RCM, Lawrie SM, Johnstone EC, Stanfield AC.
Cell-type-specific visualisation and biochemical isolation of endogenous synaptic proteins in mice.
Zhu F, Collins MO, Harmse J, Choudhary JS, Grant SGN, Komiyama NH.
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.
Brown R, Lam AD, Gonzalez-Sulser A, Ying A, Jones M, Chou RC, Tzioras M, Jordan CY, Jedrasiak-Cape I, Hemonnot AL, Abou Jaoude M, Cole AJ, Cash SS, Saito T, Saido T, Ribchester RR, Hashemi K, Oren I.
CNS macrophages differentially rely on an intronic Csf1r enhancer for their development.
Munro DAD, Bradford BM, Mariani SA, Hampton DW, Vink CS, Chandran S, Hume DA, Pridans C, Priller J.
Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial.
Goldstein LH, Robinson EJ, Mellers JDC, Stone J, Carson A, Reuber M, Medford N, McCrone P, Murray J, Richardson MP, Pilecka I, Eastwood C, Moore M, Mosweu I, Perdue I, Landau S, Chalder T; CODES study group.
Consistent use of proactive control and relation with academic achievement in childhood.
Kubota M, Hadley LV, Schaeffner S, Könen T, Meaney JA, Auyeung B, Morey CC, Karbach J, Chevalier N.
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA.
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A.
Current understanding of febrile seizures and their long-term outcomes.
Mewasingh LD, Chin RFM, Scott RC.
Disrupted inhibition may give clues in understanding neurodevelopmental disorders.
Cobb SR.
Early diagnosis of Alzheimer's disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts.
Rossini PM, Di Iorio R, Vecchio F, Anfossi M, Babiloni C, Bozzali M, Bruni AC, Cappa SF, Escudero J, Fraga FJ, Giannakopoulos P, Guntekin B, Logroscino G, Marra C, Miraglia F, Panza F, Tecchio F, Pascual-Leone A, Dubois B.
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Duman M, Vaquié A, Nocera G, Heller M, Stumpe M, Siva Sankar D, Dengjel J, Meijer D, Yamaguchi T, Matthias P, Zeis T, Schaeren-Wiemers N, Hayoz A, Ruff S, Jacob C.
Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women.
Procyshyn TL, Lombardo MV, Lai MC, Auyeung B, Crockford SK, Deakin J, Soubramanian S, Sule A, Baron-Cohen S, Bethlehem RAI.
Epilepsy deaths: Learning from health service delivery and trying to reduce risk.
Morrish P, Duncan S, Cock H.
Evaluating improvement interventions using routine data to support a learning health system: research design, data access, analysis and reporting.
Weir CJ, Heazell AEP, Whyte S, Norman JE.
Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes.
Ensor H, Weir CJ.
Evidence for 28 genetic disorders discovered by combining healthcare and research data.
Kaplanis J, Samocha KE, Wiel L, Zhang Z, Arvai KJ, Eberhardt RY, Gallone G, Lelieveld SH, Martin HC, McRae JF, Short PJ, Torene RI, de Boer E, Danecek P, Gardner EJ, Huang N, Lord J, Martincorena I, Pfundt R, Reijnders MRF, Yeung A, Yntema HG; Deciphering Developmental Disorders Study, Vissers LELM, Juusola J, Wright CF, Brunner HG, Firth HV, FitzPatrick DR, Barrett JC, Hurles ME, Gilissen C, Retterer K.
External rewards and positive stimuli promote different cognitive control engagement strategies in children.
Jin X, Auyeung B, Chevalier N.
Facilitating individuals and families affected by fragile X syndrome to participate in medication trials.
Eley SEA, McKechanie AG, Campbell S, Stanfield AC.
Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.
Vandrey B, Garden DLF, Ambrozova V, McClure C, Nolan MF, Ainge JA.
Foetal oestrogens and autism.
Baron-Cohen S, Tsompanidis A, Auyeung B, Nørgaard-Pedersen B, Hougaard DM, Abdallah M, Cohen A, Pohl A.
Grid cells are modulated by local head direction.
Gerlei K, Passlack J, Hawes I, Vandrey B, Stevens H, Papastathopoulos I, Nolan MF.
Ictal asystole - a letter within a letter.
Mbizvo GK, Derry C, Davenport R.
Incidence of early-onset epilepsy: A prospective population-based study.
Hunter MB, Yoong M, Sumpter RE, Verity K, Shetty J, McLellan A, Chin RFM.
Inhibition of Piezo1 attenuates demyelination in the central nervous system.
Velasco-Estevez M, Gadalla KKE, Liñan-Barba N, Cobb S, Dev KK, Sheridan GK.
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.
Booker SA, Simões de Oliveira L, Anstey NJ, Kozic Z, Dando OR, Jackson AD, Baxter PS, Isom LL, Sherman DL, Hardingham GE, Brophy PJ, Wyllie DJA, Kind PC.
Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex.
Pastoll H, Garden DL, Papastathopoulos I, Sürmeli G, Nolan MF.
IQ and Internalising Symptoms in Adolescents with ASD.
Edirisooriya M, Dykiert D, Auyeung B.
Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease.
McAdam RL, Morton A, Gordon SL, Alterman JF, Khvorova A, Cousin MA, Smillie KJ.
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
Hulme H, Meikle LM, Strittmatter N, van der Hooft JJJ, Swales J, Bragg RA, Villar VH, Ormsby MJ, Barnes S, Brown SL, Dexter A, Kamat MT, Komen JC, Walker D, Milling S, Osterweil EK, MacDonald AS, Schofield CJ, Tardito S, Bunch J, Douce G, Edgar JM, Edrada-Ebel R, Goodwin RJA, Burchmore R, Wall DM.
Neurobiological limits and the somatic significance of love: Caregivers' engagements with neuroscience in Scottish parenting programmes.
Broer T, Pickersgill M, Cunningham-Burley S.
Neuronal antibody prevalence in children with seizures under 3 years: A prospective national cohort.
Symonds JD, Moloney TC, Lang B, McLellan A, O'Regan ME, MacLeod S, Jollands A, Vincent A, Kirkpatrick M, Brunklaus A, Shetty J, Dorris L, Forbes K, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Findlay C, Grattan R, MacDonnell J, McKnight J, Morrison CA, Nairn L, Pilley E, Stephen E, Thomsen S, Webb A, Wilson M, Zuberi SM.
Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.
Parker RA, Weir CJ.
Normalised degree variance.
Smith KM, Escudero J.
Phenotypic impacts of CSF1R deficiencies in humans and model organisms.
Hume DA, Caruso M, Ferrari-Cestari M, Summers KM, Pridans C, Irvine KM.
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Yong XLH, Cousin MA, Anggono V.
Prenatal maternal infections and children's socioemotional development: findings from the UK Millennium Cohort Study.
Hall HA, Speyer LG, Murray AL, Auyeung B.
Proof-of-concept for a gene replacement approach to CDKL5 deficiency disorder.
Benke TA, Kind PC.
Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort.
Goldstein LH, Robinson EJ, Mellers JDC, Stone J, Carson A, Chalder T, Reuber M, Eastwood C, Landau S, McCrone P, Moore M, Mosweu I, Murray J, Perdue I, Pilecka I, Richardson MP, Medford N; CODES Study Group; CODES study group.
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Davies FCJ, Hope JE, McLachlan F, Marshall GF, Kaminioti-Dumont L, Qarkaxhija V, Nunez F, Dando O, Smith C, Wood E, MacDonald J, Hardt O, Abbott CM.
Reciprocal Developmental Relations Between ADHD and Anxiety in Adolescence: A Within-Person Longitudinal Analysis of Commonly Co-Occurring Symptoms.
Murray AL, Caye A, McKenzie K, Auyeung B, Murray G, Ribeaud D, Freeston M, Eisner M.
Rodent genetic models of neurodevelopmental disorders and epilepsy.
Gonzalez-Sulser A.
Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome.
Wong H, Hooper AWM, Niibori Y, Lee SJ, Hategan LA, Zhang L, Karumuthil-Melethil S, Till SM, Kind PC, Danos O, Bruder JT, Hampson DR.
Social cognition in adults with autism spectrum disorders: Validation of the Edinburgh Social Cognition Test (ESCoT).
Baksh RA, Abrahams S, Bertlich M, Cameron R, Jany S, Dorrian T, Baron-Cohen S, Allison C, Smith P, MacPherson SE, Auyeung B.
Species-Specificity of Transcriptional Regulation and the Response to Lipopolysaccharide in Mammalian Macrophages.
Bush SJ, McCulloch MEB, Lisowski ZM, Muriuki C, Clark EL, Young R, Pridans C, Prendergast JGD, Summers KM, Hume DA.
Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: A European Academy of Neurology, European Sleep Research Society and International League against Epilepsy-Europe consensus review.
Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L.
Subcortical nuclei volumes are associated with cognition in children post-convulsive status epilepticus: Results at nine years follow-up.
Bennett KH, Pujar SS, Martinos MM, Clark CA, Yoong M, Scott RC, Chin RFM.
Temporal trends in incidence of Rolandic epilepsy, prevalence of comorbidities and prescribing trends: birth cohort study.
Stephen J, Weir CJ, Chin RF.
The accuracy of using administrative healthcare data to identify epilepsy cases: A systematic review of validation studies.
Mbizvo GK, Bennett KH, Schnier C, Simpson CR, Duncan SE, Chin RFM.
The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.
Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK, Nicholl JP, Coates E, Biggs K, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG; ACE Consensus Group.
The association between analgesic drug use in pregnancy and neurodevelopmental disorders: protocol for an umbrella review.
Kwok J, Hall HA, Murray AL, Auyeung B.
The Dementias Platform UK (DPUK) Data Portal.
Bauermeister S, Orton C, Thompson S, Barker RA, Bauermeister JR, Ben-Shlomo Y, Brayne C, Burn D, Campbell A, Calvin C, Chandran S, Chaturvedi N, Chêne G, Chessell IP, Corbett A, Davis DHJ, Denis M, Dufouil C, Elliott P, Fox N, Hill D, Hofer SM, Hu MT, Jindra C, Kee F, Kim CH, Kim C, Kivimaki M, Koychev I, Lawson RA, Linden GJ, Lyons RA, Mackay C, Matthews PM, McGuiness B, Middleton L, Moody C, Moore K, Na DL, O'Brien JT, Ourselin S, Paranjothy S, Park KS, Porteous DJ, Richards M, Ritchie CW, Rohrer JD, Rossor MN, Rowe JB, Scahill R, Schnier C, Schott JM, Seo SW, South M, Steptoe M, Tabrizi SJ, Tales A, Tillin T, Timpson NJ, Toga AW, Visser PJ, Wade-Martins R, Wilkinson T, Williams J, Wong A, Gallacher JEJ.
The never-changing face of fragile X?
McKechanie AG, Lawrie SM, Stanfield AC.
The Secure Anonymised Information Linkage databank Dementia e-cohort (SAIL-DeC).
Schnier C, Wilkinson T, Akbari A, Orton C, Sleegers K, Gallacher J, Lyons RA, Sudlow C.
Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish.
Idigo NJ, Soares DC, Abbott CM.
Treatments in Aicardi-Goutières syndrome.
Crow YJ, Shetty J, Livingston JH.
Validating the accuracy of administrative healthcare data identifying epilepsy in deceased adults: A Scottish data linkage study.
Mbizvo GK, Schnier C, Simpson CR, Duncan SE, Chin RFM.
What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons.
Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernández A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, Kumar S, Johnsen K, Johannsson M, Jeong J, LeBeau F, Lizio R, Lopes da Silva F, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Olichney J, Onofrj M, Palop JJ, Rowan M, Stocchi F, Struzik ZM, Tanila H, Teipel S, Taylor JP, Weiergräber M, Yener G, Young-Pearse T, Drinkenburg WH, Randall F.
A chicken bioreactor for efficient production of functional cytokines.
Munro DAD, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, Dzierzak E, Kalisky T, Hohenstein P, Davies JA.
Abnormal sleep in patients with epileptic or dissociative (non-epileptic) seizures: a polysomnography study.
Popkirov S, Stone J, Derry CP.
Acquired neuromyotonia in children with CASPR2 and LGI1 antibodies.
Surana S, Kumar R, Pitt M, Hafner P, Mclellan A, Davidson J, Prabakhar P, Vincent A, Hacohen Y, Wright S.
Altered dendritic spine function and integration in a mouse model of fragile X syndrome.
Booker SA, Domanski APF, Dando OR, Jackson AD, Isaac JTR, Hardingham GE, Wyllie DJA, Kind PC.
Autism in Fragile X Syndrome; A Functional MRI Study of Facial Emotion-Processing.
McKechanie AG, Campbell S, Eley SEA, Stanfield AC.
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.
Domanski APF, Booker SA, Wyllie DJA, Isaac JTR, Kind PC.
Characteristics of 698 patients with dissociative seizures: A UK multicenter study.
Goldstein LH, Robinson EJ, Reuber M, Chalder T, Callaghan H, Eastwood C, Landau S, McCrone P, Medford N, Mellers JDC, Moore M, Mosweu I, Murray J, Perdue I, Pilecka I, Richardson MP, Carson A, Stone J; CODES Study Group.
Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice.
Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, Miyakawa T.
Computational geometry analysis of dendritic spines by structured illumination microscopy.
Kashiwagi Y, Higashi T, Obashi K, Sato Y, Komiyama NH, Grant SGN, Okabe S.
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA.
Decreased functional brain response to emotional arousal and increased psychiatric symptomology in FMR1 premutation carriers.
Brown SSG, Whalley HC, Kind PC, Stanfield AC.
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C.
Differential Dependence of GABAergic and Glutamatergic Neurons on Glia for the Establishment of Synaptic Transmission.
Turko P, Groberman K, Browa F, Cobb S, Vida I.
Differential Effects of Simulated Cortical Network Lesions on Synchrony and EEG Complexity.
Ibáñez-Molina AJ, Iglesias-Parro S, Escudero J.
Epilepsia partialis continua complicated by disseminated tuberculosis and hemophagocytic lymphohistiocytosis: a case report.
Mbizvo GK, Lentell IC, Leen C, Roddie H, Derry CP, Duncan SE, Rannikmäe K.
Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews.
Mbizvo GK, Bennett K, Simpson CR, Duncan SE, Chin RFM.
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, Story DJ, Blackwood DHR, Wyllie DJA, McIntosh AM, Millar JK, Ffrench-Constant C, Hardingham GE, Lawrie SM, Chandran S.
Fragile X-associated conditions: implications for the whole family.
McKechanie AG, Barnicoat A, Trender-Gerhard I, Allison M, Stanfield AC.
Frightening and Traumatic Memories Early after Intensive Care Discharge.
Train S, Kydonaki K, Rattray J, Stephen J, Weir CJ, Walsh TS.
Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy.
Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA.
Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy.
Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA.
GRIN2A-related disorders: genotype and functional consequence predict phenotype.
Strehlow V, Heyne HO, Vlaskamp DRM, Marwick KFM, Rudolf G, de Bellescize J, Biskup S, Brilstra EH, Brouwer OF, Callenbach PMC, Hentschel J, Hirsch E, Kind PC, Mignot C, Platzer K, Rump P, Skehel PA, Wyllie DJA, Hardingham GE, van Ravenswaaij-Arts CMA, Lesca G, Lemke JR; GRIN2A study group.
Hiding in Plain Sight: Functional Neurological Disorders in the News.
Popkirov S, Nicholson TR, Bloem BR, Cock HR, Derry CP, Duncan R, Dworetzky BA, Edwards MJ, Espay AJ, Hallett M, Lang AE, Leach JP, Lehn A, McGonigal A, Morgante F, Perez DL, Reuber M, Richardson MP, Smith P, Stamelou M, Tijssen MAJ, Tinazzi M, Carson AJ, Stone J.
How to design a dose-finding study using the continual reassessment method.
Wheeler GM, Mander AP, Bedding A, Brock K, Cornelius V, Grieve AP, Jaki T, Love SB, Odondi L, Weir CJ, Yap C, Bond SJ.
Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data.
Wilkinson T, Schnier C, Bush K, Rannikmäe K, Henshall DE, Lerpiniere C, Allen NE, Flaig R, Russ TC, Bathgate D, Pal S, O'Brien JT, Sudlow CLM; Dementias Platform UK and UK Biobank.
In Vitro Generation and Electrophysiological Characterization of OPCs and Oligodendrocytes from Human Pluripotent Stem Cells.
Magnani D, Chandran S, Wyllie DJA, Livesey MR.
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort.
Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M.
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.
Booker SA, Simões de Oliveira L, Anstey NJ, Kozic Z, Dando OR, Jackson AD, Baxter PS, Isom LL, Sherman DL, Hardingham GE, Brophy PJ, Wyllie DJA, Kind PC.
Intelligence and memory outcomes within 10 years of childhood convulsive status epilepticus.
Martinos MM, Pujar S, O'Reilly H, de Haan M, Neville BGR, Scott RC, Chin RFM.
Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model.
Muscas M, Louros SR, Osterweil EK.
Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.
Munro DAD, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, Dzierzak E, Kalisky T, Hohenstein P, Davies JA.
Neurobehavioral problems in children with early-onset epilepsy: A population-based study.
Hunter MB, Yoong M, Sumpter RE, Verity K, Shetty J, McLellan A, Jones J, Quigley A, Tallur KK, Chin RFM.
Pathogenicity and selective constraint on variation near splice sites.
Lord J, Gallone G, Short PJ, McRae JF, Ironfield H, Wynn EH, Gerety SS, He L, Kerr B, Johnson DS, McCann E, Kinning E, Flinter F, Temple IK, Clayton-Smith J, McEntagart M, Lynch SA, Joss S, Douzgou S, Dabir T, Clowes V, McConnell VPM, Lam W, Wright CF, FitzPatrick DR, Firth HV, Barrett JC, Hurles ME;
Deciphering Developmental Disorders study.
Predictors of psychotic symptoms among young people with special educational needs.
Stanfield AC, McKechanie AG, Lawrie SM, Johnstone EC, Owens DGC.
Reporting rare paediatric progressive genetic conditions: a step towards international classification.
Chin RF.
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.
Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, Hardingham GE, Wyllie DJA, Johnstone EC, Whalley HC, McIntosh AM, Lawrie SM, Chandran S.
Seizure frequency, healthcare resource utilisation and mortality in childhood epilepsy: a retrospective cohort study using the THIN database.
Myland M, Buysse B, Tsong W, Power GS, Nordli D, Chin RFM.
Severity Assessment in CDKL5 Deficiency Disorder.
Demarest S, Pestana-Knight EM, Olson HE, Downs J, Marsh ED, Kaufmann WE, Partridge CA, Leonard H, Gwadry-Sridhar F, Frame KE, Cross JH, Chin RFM, Parikh S, Panzer A, Weisenberg J, Utley K, Jaksha A, Amin S, Khwaja O, Devinsky O, Neul JL, Percy AK, Benke TA.
SuperCLEM: an accessible correlative light and electron microscopy approach for investigation of neurons and glia in vitro.
Booth DG, Beckett AJ, Prior IA, Meijer D.
Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.
Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC.
Synaptic vesicle generation from activity-dependent bulk endosomes requires a dephosphorylation-dependent dynamin-syndapin interaction.
Cheung G, Cousin MA.
Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels.
Kokotos AC, Harper CB, Marland JRK, Smillie KJ, Cousin MA, Gordon SL.
Tensor decomposition of TMS-induced EEG oscillations reveals data-driven profiles of antiepileptic drug effects.
Tangwiriyasakul C, Premoli I, Spyrou L, Chin RF, Escudero J, Richardson MP.
The CHD8 overgrowth syndrome: A detailed evaluation of an emerging overgrowth phenotype in 27 patients.
Ostrowski PJ, Zachariou A, Loveday C, Beleza-Meireles A, Bertoli M, Dean J, Douglas AGL, Ellis I, Foster A, Graham JM, Hague J, Hilhorst-Hofstee Y, Hoffer M, Johnson D, Josifova D, Kant SG, Kini U, Lachlan K, Lam W, Lees M, Lynch S, Maitz S, McKee S, Metcalfe K, Nathanson K, Ockeloen CW, Parker MJ, Pierson TM, Rahikkala E, Sanchez-Lara PA, Spano A, Van Maldergem L, Cole T, Douzgou S, Tatton-Brown K.
The evaluation and costs of transition programs for youth with epilepsy.
Nabbout R, Arzimanoglou A, Chin RFM, Grinspan Z, Speechley K, Camfield P.
The human NMDA receptor GluN2AN615K variant influences channel blocker potency.
Marwick KFM, Skehel PA, Hardingham GE, Wyllie DJA.
The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages.
Hume DA, Irvine KM, Pridans C.
The outcomes of childhood convulsive status epilepticus.
Chin RFM.
The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders.
McLachlan F, Sires AM, Abbott CM.
The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms.
Chanaday NL, Cousin MA, Milosevic I, Watanabe S, Morgan JR.
A practical guide to pre-trial simulations for Bayesian adaptive trials using SAS and BUGS.
Hansen CH, Warner P, Walker A, Parker RA, Whitaker L, Critchley HOD, Weir CJ.
Accuracy and utility of using administrative healthcare databases to identify people with epilepsy: a protocol for a systematic review and meta-analysis.
Mbizvo GK, Bennett K, Simpson CR, Duncan SE, Chin RFM.
Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11.
Kokotos AC, Peltier J, Davenport EC, Trost M, Cousin MA.
Adaptive designs in clinical trials: why use them, and how to run and report them.
Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR, Villar SS, Wason JMS, Weir CJ, Wheeler GM, Yap C, Jaki T.
Adaptive Windowing Framework for Surface Electromyogram-Based Pattern Recognition System for Transradial Amputees.
Al-Timemy AH, Bugmann G, Escudero J.
ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages.
Waddell LA, Lefevre L, Bush SJ, Raper A, Young R, Lisowski ZM, McCulloch MEB, Muriuki C, Sauter KA, Clark EL, Irvine KM, Pridans C, Hope JC, Hume DA.
AEDs or no AEDs during pregnancy? That is the question.
Chin RFM.
Amplitude- and Fluctuation-Based Dispersion Entropy.
Azami H, Escudero J.
Architecture of the Mouse Brain Synaptome.
Zhu F, Cizeron M, Qiu Z, Benavides-Piccione R, Kopanitsa MV, Skene NG, Koniaris B, DeFelipe J, Fransén E, Komiyama NH, Grant SGN.
Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors.
O'Neill N, McLaughlin C, Komiyama N, Sylantyev S.
Brain-related comorbidities in boys and men with Duchenne Muscular Dystrophy: A descriptive study.
Hendriksen RGF, Vles JSH, Aalbers MW, Chin RFM, Hendriksen JGM.
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.
Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S.
Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/- mice.
Kopanitsa MV, Gou G, Afinowi NO, Bayés À, Grant SGN, Komiyama NH.
Clinical features, course, and outcomes of a UK cohort of pediatric moyamoya.
Tho-Calvi SC, Thompson D, Saunders D, Agrawal S, Basu A, Chitre M, Chow G, Gibbon F, Hart A, Tallur KK, Kirkham F, Kneen R, McCullagh H, Mewasingh L, Vassallo G, Vijayakumar K, Wraige E, Yeo TH, Ganesan V; British Paediatric Neurology Association Moyamoya Study group.
Coarse-Graining Approaches in Univariate Multiscale Sample and Dispersion Entropy.
Azami H, Escudero J.
Cognitive impairment in early onset epilepsy is associated with reduced left thalamic volume.
Yoong M, Hunter M, Stephen J, Quigley A, Jones J, Shetty J, McLellan A, Bastin ME, Chin RFM.
Complexity analysis of spontaneous brain activity in mood disorders: A magnetoencephalography study of bipolar disorder and major depression.
Fernández A, Al-Timemy AH, Ferre F, Rubio G, Escudero J.
Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System.
Hawley CA, Rojo R, Raper A, Sauter KA, Lisowski ZM, Grabert K, Bain CC, Davis GM, Louwe PA, Ostrowski MC, Hume DA, Pridans C, Jenkins SJ.
Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review.
Weir CJ, Butcher I, Assi V, Lewis SC, Murray GD, Langhorne P, Brady MC.
Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.
Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F, Walton MK, Biggs K, Nicholl J, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG.
Discrimination of stroke-related mild cognitive impairment and vascular dementia using EEG signal analysis.
Al-Qazzaz NK, Ali SHBM, Ahmad SA, Islam MS, Escudero J.
Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.
Coba MP, Ramaker MJ, Ho EV, Thompson SL, Komiyama NH, Grant SGN, Knowles JA, Dulawa SC.
Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95.
Horner AE, McLaughlin CL, Afinowi NO, Bussey TJ, Saksida LM, Komiyama NH, Grant SGN, Kopanitsa MV.
Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder.
Tillmann J, Ashwood K, Absoud M, Bölte S, Bonnet-Brilhault F, Buitelaar JK, Calderoni S, Calvo R, Canal-Bedia R, Canitano R, De Bildt A, Gomot M, Hoekstra PJ, Kaale A, McConachie H, Murphy DG, Narzisi A, Oosterling I, Pejovic-Milovancevic M, Persico AM, Puig O, Roeyers H, Rommelse N, Sacco R, Scandurra V, Stanfield AC, Zander E, Charman T.
Evaluation of matrix factorisation approaches for muscle synergy extraction.
Ebied A, Kinney-Lang E, Spyrou L, Escudero J.
Experiential contributions to social dominance in a rat model of fragile-X syndrome.
Saxena K, Webster J, Hallas-Potts A, Mackenzie R, Spooner PA, Thomson D, Kind P, Chattarji S, Morris RGM.
Identifying dementia cases with routinely collected health data: A systematic review.
Wilkinson T, Ly A, Schnier C, Rannikmäe K, Bush K, Brayne C, Quinn TJ, Sudlow CLM; UK Biobank Neurodegenerative Outcomes Group and Dementias Platform UK.
Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex Spike Timing.
Garden DLF, Oostland M, Jelitai M, Rinaldi A, Duguid I, Nolan MF.
International variation in programmes for assessment of children's neurodevelopment in the community: Understanding disparate approaches to evaluation of motor, social, emotional, behavioural and cognitive function.
Wilson P, Wood R, Lykke K, Hauskov Graungaard A, Ertmann RK, Andersen MK, Haavet OR, Lagerløv P, Abildsnes E, Dahli MP, Mäkelä M, Varinen A, Hietanen M.
'It just opens up their world': autism, empathy, and the therapeutic effects of equine interactions.
Malcolm R, Ecks S, Pickersgill M.
Long-term behavioural outcomes after paediatric convulsive status epilepticus: a population-based cohort study.
Martinos MM, Pujar S, Gillberg C, Cortina-Borja M, Neville BGR, De Haan M, Scott RC, Chin RFM.
Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study.
Pujar SS, Martinos MM, Cortina-Borja M, Chong WKK, De Haan M, Gillberg C, Neville BG, Scott RC, Chin RF; North London Epilepsy Research Network.
Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.
Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel PA, Wyllie DJA, Jackson M.
Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study.
Jammeh EA, Carroll CB, Pearson SW, Escudero J, Anastasiou A, Zhao P, Chenore T, Zajicek J, Ifeachor E.
Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats.
Pridans C, Sauter KA, Irvine KM, Davis GM, Lefevre L, Raper A, Rojo R, Nirmal AJ, Beard P, Cheeseman M, Hume DA.
Mavoglurant in Fragile X Syndrome: Results of two open-label, extension trials in adults and adolescents.
Hagerman R, Jacquemont S, Berry-Kravis E, Des Portes V, Stanfield A, Koumaras B, Rosenkranz G, Murgia A, Wolf C, Apostol G, von Raison F.
Medical Mechatronics for Healthcare.
Liu YH, Moratal D, Escudero J, Huang HP.
Memory complaints in epilepsy: An examination of the role of mood and illness perceptions.
Tinson D, Crockford C, Gharooni S, Russell H, Zoeller S, Leavy Y, Lloyd R, Duncan S.
Modelling the details: integrating structure with function.
Wyllie DJA.
Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus.
Pridans C, Raper A, Davis GM, Alves J, Sauter KA, Lefevre L, Regan T, Meek S, Sutherland L, Thomson AJ, Clohisey S, Bush SJ, Rojo R, Lisowski ZM, Wallace R, Grabert K, Upton KR, Tsai YT, Brown D, Smith LB, Summers KM, Mabbott NA, Piccardo P, Cheeseman MT, Burdon T, Hume DA.
Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons.
Booker SA, Loreth D, Gee AL, Watanabe M, Kind PC, Wyllie DJA, Kulik Á, Vida I.
Short-term Seizure Outcomes in Childhood Epilepsy.
Aaberg KM, Bakken IJ, Lossius MI, Lund Søraas C, Tallur KK, Stoltenberg C, Chin R, Surén P.
Sinus pericranii: long-term outcome in a 10-year-old boy with a review of literature.
Goffin J, MacKenzie SA, Tallur KK, Kaliaperumal C.
Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages.
Young R, Bush SJ, Lefevre L, McCulloch MEB, Lisowski ZM, Muriuki C, Waddell LA, Sauter KA, Pridans C, Clark EL, Hume DA.
Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning.
Tennant SA, Fischer L, Garden DLF, Gerlei KZ, Martinez-Gonzalez C, McClure C, Wood ER, Nolan MF.
Study of the Mozart effect in children with epileptic electroencephalograms.
Grylls E, Kinsky M, Baggott A, Wabnitz C, McLellan A.
SYT1-associated neurodevelopmental disorder: a case series.
Baker K, Gordon SL, Melland H, Bumbak F, Scott DJ, Jiang TJ, Owen D, Turner BJ, Boyd SG, Rossi M, Al-Raqad M, Elpeleg O, Peck D, Mancini GMS, Wilke M, Zollino M, Marangi G, Weigand H, Borggraefe I, Haack T, Stark Z, Sadedin S; Broad Center for Mendelian Genomics, Tan TY, Jiang Y, Gibbs RA, Ellingwood S, Amaral M, Kelley W, Kurian MA, Cousin MA, Raymond FL.
Tensor-driven extraction of developmental features from varying paediatric EEG datasets.
Kinney-Lang E, Spyrou L, Ebied A, Chin RFM, Escudero J.
The acute medical unit model: A characterisation based upon the National Health Service in Scotland.
Reid LEM, Pretsch U, Jones MC, Lone NI, Weir CJ, Morrison Z.
The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer.
Jaarsma D, Blot FGC, Wu B, Venkatesan S, Voogd J, Meijer D, Ruigrok TJH, Gao Z, Schonewille M, De Zeeuw CI.
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
McKay S, Ryan TJ, McQueen J, Indersmitten T, Marwick KFM, Hasel P, Kopanitsa MV, Baxter PS, Martel MA, Kind PC, Wyllie DJA, O'Dell TJ, Grant SGN, Hardingham GE, Komiyama NH.
The diagnosis, burden and prognosis of dementia: A record-linkage cohort study in England.
Pujades-Rodriguez M, Assi V, Gonzalez-Izquierdo A, Wilkinson T, Schnier C, Sudlow C, Hemingway H, Whiteley WN.
The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche.
Sehgal A, Donaldson DS, Pridans C, Sauter KA, Hume DA, Mabbott NA.
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.
Scott CL, T'Jonck W, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A, Saeys Y, Guilliams M.
Trends in epilepsy admissions in children, 1981-2013: population-based observational study using the Scottish national hospital discharge database.
Chin RFM, Stephen J, Weir CJ, Wood R.
Using FM Dyes to Monitor Clathrin-Mediated Endocytosis in Primary Neuronal Culture.
Cousin MA, Gordon SL, Smillie KJ.
Brain-related comorbidities in boys and men with Duchenne Muscular Dystrophy: A descriptive study.
Authors
Hendriksen RGF, Vies JSH, Aalbers MW, Chin RFM, Hendriksen JGM. Eur J Paediatr Neurol. 2017 Dec.
Description
In a Dutch-Scottish collaboration study with questionnaires directed to an international population, this study suggests that almost one in thirteen children with Duchenne have epilepsy and that other brain-related comorbidities were higher if both conditions co-existed. However, the study may have been biased because there was not a universal response so future studies are needed to determine true incidence.
Long-term behavioural outcomes after paediatric convulsive status epilepticus: a population-based cohort study.
Authors
Martinos MM, Pujar S, Gillberg C, Cortina-Borja M, Neville BGR, De Haan M, Scott RC, Chin RFM. Dev Med Child Neurol. 2017 Dec.
Description
Having established the first study focused on prolonged seizures in children, Chin and colleagues followed this unique cohort for 8 years after their initial episode of prolonged seizures to determine behavioural outcomes. Just over a quarter had a behavioural/psychiatric disorder (including ADHD and autism spectrum disorders) with those who had epilepsy at the time of the prolonged seizures being more severely affected. Repeated episodes of prolonged seizures or having had previous seizures before the initial episode increases the risk for subsequent problems.
Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group.
Authors
Leach JP, Smith PE, Craig J, Bagary M, Cavanagh D, Duncan S, Kelso ARC, Marson AG, McCorry D, Nashef L, Nelson-Piercy C, Northridge R, Sieradzan K, Thangaratinam S, Walker M, Winterbottom J, Reuber M. Seizure. 2017 Aug; 50:67-72.
Description
This paper summarises findings of a multidisciplinary meeting with representation from a wide group of professional bodies aimed at producing the best epilepsy pregnancy care to reduce mortality in expectant mothers with epilepsy, and reduce problems in their children. The authors identified Golden Moments of opportunities for improving outcomes, Key Groups to making change, and aimed to have these improvements in place by 2020.
Monitoring activity-dependent bulk endocytosis with the genetically-encoded reporter VAMP4-pHluorin.
Authors
Nicholson-Fish JC, Smillie KJ, Cousin MA. J Neurosci Methods. 2016 Jun; 266: 1-10.
Description
Having previously shown that abnormalities in activity-dependent bulk endocytosis may be implicated as a cause for epilepsy, and a potential target for development of novel antiepileptic drugs, the authors provide a new method to monitor the endocytosis mode.
Accounting for the complex hierarchical topology of EEG phase-based functional connectivity in network binarisation.
Authors
Smith K, Absalo D, Escudero J. PLoS One. 2017 Oct; 12(10).
Description
There is evidence of interconnectivity of different parts of the brain, with varying degrees of network connectivity. How to measure these networks using imaging and EEG techniques, and how networks are involved in normal learning and behaviour as well as in diseases of the brain are a major research focus in laboratories worldwide. In this paper, the authors provide new evidence of the importance of considering a large number of edges in EEG connectivity network research.
Discrimination of stroke-related mild cognitive impairment and vascular dementia using EEG signal analysis.
Authors
Al-Qazzaz NK, Ali SHBM, Ahmad SA, Islam MS, Escudero J. Med Biol Eng Comput. 2017 Nov.
Description
EEGs are often used primarily for diagnosis and monitoring treatment of seizures. However, there is increasing use of EEG in identifying problems in learning and behaviour. Dr Escudero and colleagues demonstrate novel analytical methods of EEGs that may help in distinguishing between patients with stroke related cognitive problems and those with vascular dementia.
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women.
Authors
Bethlehem RAI, Lombardo MV, Lai MC, Auyeung B, Crockford SK, Deakin J, Soubramanian S, Sule A, Kundu P, Voon V, Baron-Cohen S. Transl Psychiatry. 2017 Apr; 7(4).
Description
The cause for gender differences in the incidence of different types of epilepsy and associated comorbidity is often unclear. This paper demonstrates that the naturally occurring hormone oxytocin affects brain connectivity in women. This may contribute to the differences in subsets of people with neurological conditions, including epilepsy.
Flexible theta sequence compression mediated via phase precessing interneurons.
Authors
Chadwick A, Van Rossum MC, Nolan MF. Elife. 2016 Dec; 5.
Description
Abnormalities in the function of specific brain cells, interneurons, are a possible cause for seizures in people with epilepsy. Learning problems are common in people with epilepsy, independent of seizure control, but the mechanism for these problems are unclear. In this study, Matt Nolan and colleagues demonstrate a mechanism of encoding information through interneuron-dependent brain rhythms.
Providing experiential information on early medical abortion: a qualitative evaluation of an animated personal account, Lara's Story.
Authors
Sherman S, Harden J, Cattanach D, Cameron ST. J Fam Plann Reprod Health Care. 2017 Oct; 43(4).
Description
Data on a doctoral project being supervised by MMEC’s Jeni Harden, one of the authors of this paper, show children with epilepsy often have limited knowledge about epilepsy. Publicly readily available information about epilepsy, aside from written information, specifically designed with children with mind are sparse. The current study shows that an animated film on early medical abortion might be valuable in providing information for women considering this procedure. Extrapolating from this, an animation film about epilepsy could be helpful in providing children with much needed information about the disease.
Linking routinely collected social work, education and health data to enable monitoring of the health and health care of school-aged children in state care ('looked after children') in Scotland: a national demonstration project.
Authors
Clark D, King A, Sharpe K, Connelly G, Elliott L, Macpherson LMD, McMahon AD, Milligan I, Wilson P, Conway DI, Wood R. Public Health. 2017 Sep; 150.
Description
Dr Wood and colleagues demonstrate the strong potential of linking Scotland’s routine administrative social, education and health data to investigate the health outcomes of school aged children. By extending their method they propose to be able to include information on children who are not in public funded schooling.
Seizures, syndromes, and etiologies in childhood epilepsy: The International League Against Epilepsy 1981, 1989, and 2017 classifications used in a population-based cohort.
Authors
Aaberg KM, Surén P, Søraas CL, Bakken IJ, Lossius MI, Stoltenberg C, Chin R. Epilepsia. 2017 Sep.
Description
In one of the first published studies to use the new ILAE classification scheme for epilepsy, and apply it to the largest validated and phenotyped epilepsy cohorts identified from a birth cohort worldwide, the Norway-UK researchers show: (1) the new classification allows for a greater precision in diagnoses which may help with prognosis, treatment and trying to find causes but as this requires detailed investigative results, may result in more epilepsies being unclassifiable pending results/availability of tests. (2) Despite advances in technology, the cause of epilepsy still remains unknown in most children.
RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.
Authors
Reijnders MRF, Ansor NM, Kousi M, Yue WW, Tan PL, Clarkson K, Clayton-Smith J, Corning K, Jones JR, Lam WWK, Mancini GMS, Marcelis C, Mohammed S, Pfundt R, Roifman M, Cohn R, Chitayat D; Deciphering Developmental Disorders Study, Millard TH, Katsanis N, Brunner HG, Banka S. Am J Hum Genet. 2017 Sep; 101(3).
Description
Dr Lam and colleagues through an international collaborative study reveals the role of mutations in RAC1 gene in neurodevelopmental disorders
Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder.
Authors
Harper CB, Mancini GMS, van Slegtenhorst M, Cousin MA. Neurobiol Dis. 2017 Sep; 108.
Description
MMEC Pre-clinical lead Mike Cousin and his team reveal a form of severe intellectual disability and epilepsy found in a single patient was caused by a mutation in the SYP gene. They went on to show that this mutation specifically affected movement of a key protein for neuron communication – synaptobrevin II. They showed that this defect was also seen with other human mutations in SYP, this time from X-linked intellectual disability. Therefore correcting the altered movement of synaptobrevin II may be a potential avenue for therapeutic intervention in both epilepsy and intellectual disability.
Investigating Sex Bias in the AQ-10: A Replication Study.
Authors
Murray AL, Booth T, Auyeung B, McKenzie K, Kuenssberg R. Assessment. 2017 Sep; 1073191117733548.
Description
Autism is a common comorbidity in epilepsy and those on the milder end of the spectrum can be difficult to identify. Thus, screening methods for autism are important. This study confirms that a novel screening instrument (AQ-10) which determines who would benefit from more detailed testing, is not biased against females. Nonetheless the authors suggest one item to be replaced.
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
Authors
Thomson SR, Seo SS, Barnes SA, Louros SR, Muscas M, Dando O, Kirby C, Wyllie DJA, Hardingham GE, Kind PC, Osterweil EK. Neuron. 2017 Aug; 95(3).
Description
Fragile X syndrome (FXS) is the most common form of inherited X-linked intellectual disability, with patients often displaying epilepsy. FXS is thought to be caused by excessive synthesis of specific types of proteins controlled by FMRP, which is mutated in FXS. . The Osterweil group showed common FXS symptoms (including seizures) can be reversed in a model system by activating a pathway dependent on the neurotransmitter acetylcholine. Interestingly proteins for this pathway are increased in FXS, showing that enhancement of specific proteins may be beneficial preventing FXS symptoms, including seizures.
Familial epilepsy with anterior polymicrogyria as a presentation of COL18A1 mutations.
Authors
Corbett MA, Turner SJ, Gardner A, Silver J, Stankovich J, Leventer RJ, Derry CP, Carroll R, Ha T, Scheffer IE, Bahlo M, Jackson GD, Mackey DA, Berkovic SF, Gecz J. Eur J Med Genet. 2017 Aug; 60(8).
Description
Chris Derry from MMEC and colleagues discover mutations in COL18A1 gene in four sisters. These sisters display Lennox-Gastaut type severe refractory epilepsy and abnormality in the formation of the front of the brain. This finding is novel since it identifies a genetic, inherited cause for Lennox Gastatut Syndrome. Previously this genetic mutation was usually found in another neurological disorder therefore this study expands the types of diseases/conditions that occur due to abnormalities in COL18A1.
Estimating numbers of children with cerebral palsy: a call to action.
Authors
Wood R. Dev Med Child Neurol. 2017 Aug; 59(8).
Description
Dr. Wood comments on an original article by Glinianaia et al. on “Predicting the prevalence of cerebral palsy by severity level in children aged 3 to 15 years across England and Wales by 2020” Dr. Wood emphasises that the key message arising from the paper by Glinianaia et al. is that, austerity and service cuts notwithstanding, the need for robust, integrated services for children (and their families) with complex needs is unlikely to diminish in the short to medium term. Regardless of advances in prevention, there will always be children with significant impairment and disability, and how we collectively organize and deliver services to meet their needs will remain a measure of our society.
Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group.
Authors
Leach JP, Smith PE, Craig J, Bagary M, Cavanagh D, Duncan S, Kelso ARC, Marson AG, McCorry D, Nashef L, Nelson-Piercy C, Northridge R, Sieradzan K, Thangaratinam S, Walker M, Winterbottom J, Reuber M. Seizure. 2017 Aug; 50.
Description
Susan Duncan, head of the adult epilepsy service in Edinburgh, and other members of the UK wide epilepsy mortality group put forward suggestions to optimise pregnancy care in women with epilepsy. The aim is to reduce maternal mortality and morbidity in children exposed to anti-epileptic medication whilst they are in the womb.
Can the Apgar Score be Used for International Comparisons of Newborn Health?
Authors
Siddiqui A, Cuttini M, Wood R, Velebil P, Delnord M, Zile I, Barros H, Gissler M, Hindori-Mohangoo AD, Blondel B, Zeitlin J; Euro-Peristat Scientific Committee. Paediatr Perinat Epidemiol. 2017 Jul; 31(4).
Description
The APGAR Score, usually given at 1 minute, 5 minutes, and 10 minutes after birth is often used to predict mortality within the first month of life. Furthermore lower scores are associated with long term health problems in children who survive past the first month of life. Dr. Wood and colleagues show that there is a large variation in APGAR scoring amongst countries, likely due to national scoring practices, makes the APGAR score an unsuitable indicator for comparing health in the newborn across countries.
Incidence and Prevalence of Childhood Epilepsy: A Nationwide Cohort Study.
Authors
Aaberg KM, Gunnes N, Bakken IJ, Lund Søraas C, Berntsen A, Magnus P, Lossius MI, Stoltenberg C, Chin R, Surén P. Pediatrics. 2017 May;139(5).
Description
In the second of a series of papers from a collaboration between the Norwegian Institute of Public Health and the University of Edinburgh, the researchers provide up to date information on the incidence of childhood epilepsy. The importance, strength and merits of analysing data collected routinely in clinical practice, often referred to as “Big Data” is increasingly being recognised. This paper demonstrates the importance of the validation of epilepsy diagnoses in such data, since a third of children can be erroneously coded as having epilepsy when they do not. The now validated epilepsy cohort is part of a much larger birth cohort and will allow the researchers to examine the development of children with epilepsy compared to those without, the prenatal and postnatal factors that lead to an increased risk for epilepsy and related neurodevelopmental problems, and factors that improve outcomes.
Long-term white matter tract reorganization following prolonged febrile seizures.
Authors
Pujar SS, Seunarine KK, Martinos MM, Neville BG, Scott RC, Chin RF, Clark CA. Epilepsia. 2017 May;58(5):772-780.
Description
Febrile seizures occur in 3 per 100 children between the ages of 6 months to 5 years. They generally last less than 5 minutes but can go on for longer than 30 minutes. These longer seizures, prolonged febrile seizures, are thought to cause brain damage. In this study of a unique group of children with prolonged febrile seizures, researchers from UCL and the University of Edinburgh report findings that suggest prolonged febrile seizures can interfere with usual development of how different parts of the brain connect with each other but adopts to this within 8 years through changes in the microstructure and organisation of the connective tracts of the brain.
Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice.
Authors
Davies FC, Hope JE, McLachlan F, Nunez F, Doig J, Bengani H, Smith C, Abbott CM.
Description
Mutations in the gene EF1A2 have recently been found to give rise to neurodevelopmental disorders. In pre-clinical studies, the researchers produced mice with the mutation G70S (the most frequently occurring mutation in humans) in the eEF1A2 gene some of which have seizures and sudden death. They conclude that the abnormal protein formed due to this gene mutation is essentially non-functional, suggesting this disorder results from loss of normal eEF1A2 function
Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy.
Authors
Currie SP, Luz LL, Booker SA, Wyllie DJ, Kind PC, Daw MI. Epilepsia. 2017 Apr;58(4):597-607.
Description
Developmental concerns and or problems can exist prior to the onset of seizures. Why cognitive and behavioural problems occur in a high proportion of people with epilepsy is unclear. This study shows that in an experimental model of a specific type of epilepsy, childhood absence epilepsy, there are changes in the way that the brain is usually connected PRIOR to the onset of seizures.
A (free) radical approach reveals the physiological function of different synaptic vesicle pools.
Authors
Cousin MA. J Physiol. 2017 Feb 15;595(4):1005-1006.
Description
Synaptic vesicles (SVs) store neurotransmitter inside brain cells and during neuronal activity are triggered to release their contents to evoke neuronal communication. This short commentary article highlighted our growing understanding that not all SVs are created equal, and that there are different populations that mediate different types of neurotransmission. This may be important for neurotransmitter release during epilepsy, and identifying which SVs are responsible may allow excessive neurotransmission to be limited.
Alterations in the properties of neonatal thalamocortical synapses with time in in vitro slices.
Authors
Luz LL, Currie SP, Daw MI. PLoS One. 2017 Feb 8;12(2):e0171897.
Description
Preclinical, non-human studies are important to increase understanding of and development of treatments for epilepsy. Brain cells are constantly being formed and lost in the living brain with those that remain forming connections between them. This study shows the way that brain cells communicate with each other in experimental studies of brain slices in specialised preparations changes over time. Thus, in experiments using this technique, this has to be borne in mind.
The complex hierarchical topology of EEG functional connectivity.
Authors
Smith K, Escudero J. J Neurosci Methods. 2017 Jan 30;276:1-12.
Description
EEGs have traditionally been used to help in the diagnosis and treatment of epilepsy. There is increasing interest in using EEG to develop networks to enhance our understanding of how the brain is connected and how it works. This paper provides insight into the complex ways that brain networks are organised.
Grid cells' need for speed.
Authors
Gonzalez-Sulser A, Nolan MF. Nat Neurosci. 2016 Dec 27;20(1):1-2.
Description
Grid-firing fields of neurons in the entorhinal cortex are thought to require inputs encoding running speed. Glutamatergic projections from the medial septum may be one of the inputs that provide these speed signals.
5-Hydroxyvitamin D concentration in paediatric cancer patients from Scotland: a prospective cohort study.
Authors
Iniesta RR, Paciarotti I, Davidson I, McKenzie JM, Brand C, Chin RF, Brougham MF, Wilson DC. Br J Nutr. 2016 Dec;116(11):1926-1934.
Description
This study showed that in Scotland, children with cancer are at no higher risk of having low Vitamin D levels compared to children in the general Scottish population. However, in both groups, low levels are common. Older children with cancer, or those who are overweight or not taking vitamin D supplements are more likely to have low levels. The study collaborators in oncology, gastroenterology and neurology services at the Royal Hospital for Sick Children in Edinburgh recommended that supplementation and monitoring should implemented. Vitamin D levels in the “healthy” control group of children were obtained through a parallel study funded by the Roald Dahl Marvellous Children’s Charity, examining Vitamin D levels in Scottish children with epilepsy versus those without.
Flexible theta sequence compression mediated via phase precessing interneurons.
Authors
Chadwick A, van Rossum MC, Nolan MF. Elife. 2016 Dec 8;5.
Description
The brain electrical activity varies throughout the day and even at the same time period, there can be marked variation of electrical activity within different parts of the brain. These electrical activities have a rhythm and are described as oscillations. Maintenance of these oscillations are linked to learning and if they become abnormal could be associated with development of seizures. In this paper, the authors report on how the medial septum of the brain (a potential target for novel epilepsy treatments) influences oscillations.
Quantifying and exploring camouflaging in men and women with autism.
Authors
Lai MC, Lombardo MV, Ruigrok AN, Chakrabarti B, Auyeung B, Szatmari P, Happé F, Baron-Cohen S; MRC AIMS Consortium. Autism. 2016 Nov 29.
Description
The co-occurrence of epilepsy and autism is common. From a study carried out by a consortium of researchers, Dr. Auyeung and colleagues investigated if and how people with autism “camouflage” their social communication difficulties. They found that the degree of camouflaging was not significantly influenced by age or IQ. On average, women with autism had higher camouflaging scores than men with autism with substantial variability in both groups. Greater camouflaging was associated with more depressive symptoms in men.
Investigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ-10.
Authors
Murray AL, Allison C, Smith PL, Baron-Cohen S, Booth T, Auyeung B. Autism Res. 2016 Nov 28.
Description
There are more than 40 different types of epilepsy, and there are many autism spectrum conditions (ASC). This study addresses the possibility of misdiagnosis or underdiagnosis using the AQ-10, a screening test for ASC recommended by the National Institute of Clinical Excellence. Dr. Auyeung and colleagues show that some items were biased towards males and others to females but overall there was no bias. This supports the continued use of AQ-10 as a screening test, but caution should be exercised when interpreting responses to individual items.
Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders.
Authors
Ruth R. Shah, Justyna Cholewa-Waclaw, Faith C.J. Davies, Katie M. Paton, Ronan Chaligne, Edith Heard, Catherine M. Abbott, Adrian P. Bird. Wellcome Open Res. 2016 Nov 15; 1: 13.
Description
There is increasing evidence of the role of genetic abnormalities in diseases of the nervous system, including epilepsy. Identification of a genetic abnormality is insufficient on its own and more work is needed to understand the changes in function that result from this event and thus the changes in biology in humans. Understanding this can be highly beneficial with prognostication and development of therapies. In this paper, Prof Abbott and colleagues show how a novel technique CRISPR/Cas 9 can be used to introduce genetic abnormalities in human brain cells. This is usually a very difficult process for brain cells that are grown in dishes. This new work opens up potential to study the mechanism of human brain diseases including Rett Syndrome and EEF1A2 disorder.
Continuous attractor network models of grid cell firing based on excitatory-inhibitory interactions.
Authors
Shipston-Sharman O, Solanka L, Nolan MF. J Physiol. 2016 Nov 15;594(22):6547-6557.
Description
Seizures arise because of an imbalance between excitatory and inhibitory mechanisms in the brain. In this paper, the authors discuss evidence for continuous attractor network models that account for grid firing by synaptic interactions between excitatory and inhibitory cells.
Seizure variables and their relationship to genotype and functional abilities in the CDKL5 disorder.
Fehr S, Wong K, Chin R, Williams S, de Klerk N, Forbes D, Krishnaraj R, Christodoulou J, Downs J, Leonard H. Neurology. 2016 Nov;87(21):2206-2213.
Expanding the (kaleido)scope: exploring current literature trends for translating electroencephalography (EEG) based brain-computer interfaces for motor rehabilitation in children.
Kinney-Lang E, Auyeung B, Escudero J. Journal of Neural Engineering. 2016 Oct;13(6).
Comorbidity and childhood epilepsy: A nationwide registry study.
Aaberg KM, Bakken IJ, Lossius MI, Lund Soraas C, Haberg SE, Stoltenberg C, Suren P, Chin R. Pediatrics. 2016 Aug;138(3).
Refined composite multivariate generalized multiscale fuzzy entropy: A tool for complexity analysis of multichannel signals.
Azami H, Escudero J. Physica A: Statistical Mechanics and its Applications. 2016 Aug;465:261-276.
Families' experiences of living with pediatric epilepsy: A qualitative systematic review.
Harden J, Black R, Chin RF. Epilepsy Behav. 2016 Jul;60:225-237.
Local field potentials get funny.
Nolan MF. The Journal of Physiology. 2016 Jul;594(13):3487-3488.
Monitoring activity-dependent bulk endocytosis with the genetically-encoded reporter VAMP4-pHluorin.
Nicholson-Fish JC, Smillie KJ, Cousin MA. J Neurosci Methods. 2016 Jun;266:1-10.
Amplitude-aware permutation entropy: Illustration in spike detection and signal segmentation.
Authors
Azami H, Escudero J. Comput Methods Programs Biomed. 2016 May;128:40-51.
Description
The detection of spikes on EEGs is an important part of the diagnosis and treatment of epilepsy. Seizure detection devices rely on automated detection of such spikes but if there are irregularities in the trace from movement or other artefacts, this can be difficult or impossible. The authors report their discovery of a novel method of detecting spikes and announce the free availability of the code.
Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability.
Lam WWK, Millichap JJ, Soares DC, Chin R, McLellan A, FitzPatrick DR, Elmslie F, Lees MM, Schaefer GB, DDD study, Abbott CM. Molecular Genetics & Genomic Medicine. 2016 Apr;4(4):465-474.
Definition and diagnostic criteria of sleep-related hypermotor epilepsy.
Tinuper P, Bisulli F, Cross JH, Hesdorffer D, Kahane P, Nobili L, Provini F, Scheffer IE, Tassi L, Vignatelli L, Bassetti C, Cirignotta F, Derry C, Gambardella A, Guerrini R, Halasz P, Licchetta L, Mahowald M, Manni R, Marini C, Mostacci B, Naldi I, Parrino L, Picard F, Pugliatti M, Ryvlin P, Vigevano F, Zucconi M, Berkovic S, Ottman R. The Official Journal of the American Academy of Neurology. 2016 Apr;86(19):1834-1842.
Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals.
Nicholson-Fish JC, Cousin MA, Smillie KJ. Neurochem Res. 2016 Mar;41(3):534-543.
After sudden unexpected death in epilepsy: Lessons learned and the road forward.
Donner EJ, Waddell B, Osland K, Leach JP, Duncan S, Nashef L, Picot MC. Epilepsia. 2016 Jan;57(S1):46-53.
Improved multiscale permutation entropy for biomedical signal analysis: Interpretation and application to electroencephalogram recordings.
Azami H, Escudero J. Biomedical Signal Processing and Control. 2016 Jan;23:28-41.
VAMP4 is an essential cargo molecule for activity-dependent bulk endocytosis.
Nicholson-Fish JC, Kokotos AC, Gillingwater TG, Smillie KJ, Cousin MA. Neuron. 2015 Dec;88(5):973-984.
Selection of Mother Wavelet Functions for Multi-Channel EEG Signal Analysis during a Working Memory Task.
Al-Qazzaz NK, Bin Mohd Ali SH, Ahmad SA, Islam MS, Escudero J. Sensors (Basel). 2015 Nov;15(11):29015-29035.
Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice.
Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nagerl UV, Kind PC, Wyllie DJ. Journal of Neuroscience. 2015 Nov;35(45):15073-15081.
Features of developmental coordination disorder in active childhood epilepsy: a population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Dev Med Child Neurol. 2015 Sep;57(9):829-34.
Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis.
Morton A, Marland JR, Cousin MA. J Neurochem. 2015 Aug;134(3):405-15.
The health, education, and social care costs of school-aged children with active epilepsy: A population-based study.
Hunter RM, Reilly C, Atkinson P, Das KB, Gillberg C, Chin RF, Scott RC, Neville BG, Morris S. Epilepsia. 2015 Jul;56(7):1056-64.
Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks.
Solanka L, van Rossum MC, Nolan MF. eLife. 2015 Jul;4.
Prescription of emergency antiepileptic medication after a first childhood seizure: analysis of routine administrative data.
Chin RF, Ajetunmobi O, Weir CJ, Wood R. Epileptic Disord. 2015 Jun;17(2):172-6.
Factors associated with quality of life in active childhood epilepsy: A population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, and Neville BG. Eur J Paediatr Neurol. 2015 May;19(3):308-13.
Cognition in school-aged children with "active" epilepsy: A population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. J Clin Exp Neuropsychol. 2015 Apr;37(4):429-38.
Socioeconomic deprivation is an independent risk factor for behavioral problems in children with epilepsy.
Carson J, Weir A, Chin RF, McLellan A. Epilepsy Behav. 2015 Apr;45:105-9.
Quantifying the deficit – imaging neurobehavioural impairment in childhood epilepsy.
Yoong, M. Quan. Imaging in Med Surg. 2015 April 5(2): 225-237.
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.
Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, and Alessi DR. J Neurosci. 2015 Feb 11;35(6):2492-507.
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M. Nat Med. 2015 Jan;21(1):19-26.
Laminar and dorsoventral molecular organization of the medial entorhinal cortex revealed by large-scale anatomical analysis of gene expression.
Ramsden HL, Sürmeli G, McDonagh SG, Nolan MF. PLOS Computational Biology. 2015 Jan;11(1).
Features of autism spectrum disorder (ASD) in childhood epilepsy: a population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Epilepsy Behav. 2015 Jan;42:86-92.
A qualitative study of the reactions of young adults with epilepsy to SUDEP disclosure, perceptions of risks, views on the timing of disclosure and behavioural change.
Tonberg A. Harden J, McLellan A, Chin RF, Duncan S. Epilepsy Behav. 2015 Jan;42:98-106.
Screening for mental health disorders in active childhood epilepsy: Population-based data.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Epilepsy Res. 2014 Dec; 108(10):1917-26.
Parent- and Teacher-Reported Symptoms of ADHD in School-Aged Children With Active Epilepsy: A Population-Based Study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. J Atten Disord. 2014 Nov 21.
'If you're gonna die, you're gonna die': Young adults' perceptions of sudden unexpected death in epilepsy.
Harden J, Tonberg A, Chin RF, McLellan A, Duncan S. Chronic Illn. 2014 Oct 31.
Academic achievement in school-aged children with active epilepsy: A population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Epilepsia. 2014 Oct 20.
What are the best ways to deliver benzodiazepines in children/patients with prolonged convulsive seizures?
Chin RF. Epileptic Disord. 2014 Oct;16 Suppl 1:50-8.
Application of diffusion tensor imaging and tractography of the optic radiation in anterior temporal lobe resection for epilepsy: a systematic review.
Piper RJ, Yoong MM, Kandasamy J, Chin RF. Clin Neurol Neurosurg. 2014 Sep; 124:59-65.
Convulsive status epilepticus and health-related quality of life in children with epilepsy.
Ferro MA, Chin RF, Camfield CS, Wiebe S, Levin SD, Speechley KN. Neurology. 2014 Aug 19;83(8):752-7.
Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus.
Piper RJ, Yoong MM, Pujar S, Chin RF. Brain Behav. 2014 Aug 28.
Convulsive status epilepticus and health-related quality of life in children with epilepsy.
Ferro MA, Chin RF, Camfield CS, Wiebe S, Levin SD, Speechley KN. Neurology, 2014 Aug 19;83(8):752-7.
Hippocampal sclerosis and other forms of status epilepticus.
Yoong M, Martinos MM, Pujar S, Scott RC, Chin RF.Ann Neurol. 2014 Aug;76(2):316.
Neurobehavioral comorbidities in children with active epilepsy: a population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Pediatrics. 2014 Jun;133(6):e1586-93.
Sleeping in fits and starts: a practical guide to distinguishing nocturnal epilepsy from sleep disorders.
Derry CP. Pract Neurol. 2014 Jun 9. pii: practneurol-2014-000890.
Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination.
Kegel L, Jaegle M, Driegen S, Aunin E, Leslie K, Fukata Y, Watanabe M, Fukata M, Meijer D. Development. 2014 Apr;141(8):1749-56.
Sleep tight, wake up bright. Should sleep deprivation be included as a potential risk factor for SUDEP?
Scorza FA, Duncan S, Cavalheiro EA, Scorza CA, Tufik S, Andersen ML. Epilepsy Behav. 2014 Apr; 33:75-6.
Control of synaptic vesicle endocytosis by an extracellular signalling molecule.
Smillie KJ, Pawson J, Perkins EM, Jackson M, Cousin MA.
Determinants of adult functional outcome in adolescents receiving special educational assistance.
McGeown HR, Johnstone EC, McKirdy J, Owens DC, Stanfield AC.
Early death in those previously hospitalised for mental healthcare in Scotland: a nationwide cohort study, 1986-2010.
Ajetunmobi O, Taylor M, Stockton D, Wood R.
Epilepsy health consumer groups and charities; how representative of patients are they? The results of a pilot study.
Grinton M, Leavy Y, Ahern D, Hughes F, Duncan S.
Feedback inhibition enables θ-nested γ oscillations and grid firing fields.
Pastoll H, Solanka L, van Rossum MC, Nolan MF.
From 'implications' to 'dimensions': science, medicine and ethics in society.
Pickersgill MD.
HCN1 channels in cerebellar Purkinje cells promote late stages of learning and constrain synaptic inhibition.
Rinaldi A, Defterali C, Mialot A, Garden DL, Beraneck M, Nolan MF.
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.
Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE.J
In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy
Jennifer Doig , Lowri A Griffiths, David Peberdy, Permphan Dharmasaroja, Maria Vera, Faith J C Davies, Helen J Newbery, David Brownstein, Catherine M Abbott
Longitudinal gray matter change in young people who are at enhanced risk of schizophrenia due to intellectual impairment.
Moorhead TW, Stanfield AC, McKechanie AG, Dauvermann MR, Johnstone EC, Lawrie SM, Cunningham Owens DG.
Mapping the new molecular landscape: social dimensions of epigenetics.
Pickersgill M, Niewöhner J, Müller R, Martin P, Cunningham-Burley S.
Mild traumatic brain injury and epilepsy: alcohol misuse may underpin the association.
Welch KA, Derry C.J
Moving from a universal to targeted child health programme: which children receive enhanced care? A population-based study using routinely available data.
Wood R, Stockton D, Brown H.
Munc18-1 protein molecules move between membrane molecular depots distinct from vesicle docking sites.
Smyth AM, Yang L, Martin KJ, Hamilton C, Lu W, Cousin MA, Rickman C, Duncan RR.J
Prolonged febrile seizures cause reversible reductions in white matter integrity.
Yoong M, Seunarine K, Martinos M, Chin RF, Clark CA, Scott RC.
Quality of life in a cohort of men with epilepsy compared to a healthy population and those with common chronic diseases in the UK using a generic patient-reported outcome measure.
Greenway L, Ahern D, Leavy Y, Rawnsley M, Duncan S.
Sleep and epilepsy.
Derry CP, Duncan S.
Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin.
Cheung G, Cousin MA.
The social life of the brain: Neuroscience in society.
Pickersgill MD.
The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.
Gordon SL, Cousin MA.
Trends in emergency hospital admissions of children: observations from Scotland.
Wood R, Blair M, Wilson P.
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