Publications
This section provides links to selected publications, published both online and in print.
Publications are listed in chronological order, the first being the most recent.
A consensus protocol for functional connectivity analysis in the rat brain
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, Célestine M, Chavez-Negrete JE, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes FF, Fowler CF, Fuentes-Ibañez A, Garin CM, Gelderman E, Golden CEM, Guo CCG, Henckens MJAG, Hennessy LA, Herman P, Hofwijks N, Horien C, Ionescu TM, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee SH, Lillywhite A, Liu Y, Liu YY, López-Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan MJ, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens DMP, Nava-Gomez LJ, Nonaka H, Ortiz JJ, Paasonen J, Peeters LM, Pereira M, Perez PD, Pompilus M, Prior M, Rakhmatullin R, Reimann HM, Reinwald J, Del Rio RT, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten TJ, Ryoke R, Sack M, Salvan P, Sanganahalli BG, Schroeter A, Seewoo BJ, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith JAB, Smith C, Sobczak F, Stenroos PJ, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García ME, Tudela R, van den Berg M, van der Marel K, et al.
A functional MRI facial emotion-processing study of autism in individuals with special educational needs
Ciani O, Manyara AM, Davies P, Stewart D, Weir CJ, Young AE, Blazeby J, Butcher NJ, Bujkiewicz S, Chan AW, Dawoud D, Offringa M, Ouwens M, Hróbjartssson A, Amstutz A, Bertolaccini L, Bruno VD, Devane D, Faria CDCM, Gilbert PB, Harris R, Lassere M, Marinelli L, Markham S, Powers JH, Rezaei Y, Richert L, Schwendicke F, Tereshchenko LG, Thoma A, Turan A, Worrall A, Christensen R, Collins GS, Ross JS, Taylor RS.
A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection
Calvert C, Carruthers J, Denny C, Donaghy J, Hopcroft LEM, Hopkins L, Goulding A, Lindsay L, McLaughlin T, Moore E, Taylor B, Loane M, Dolk H, Morris J, Auyeung B, Bhaskaran K, Gibbons CL, Katikireddi SV, O'Leary M, McAllister D, Shi T, Simpson CR, Robertson C, Sheikh A, Stock SJ, Wood R.
Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons
Sharma SD, Reddy BK, Pal R, Ritakari TE, Cooper JD, Selvaraj BT, Kind PC, Chandran S, Wyllie DJA, Chattarji S.
Case-control study developing Scottish Epilepsy Deaths Study Score to predict epilepsy-related death
Mbizvo GK, Schnier C, Simpson CR, Duncan SE, Chin RFM.
Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-analysis
Mazzone PP, Hogg KM, Weir CJ, Stephen J, Bhattacharya S, Chin RFM.
COVID-19 vaccination uptake in people with epilepsy in Wales
Strafford H, Lacey AS, Hollinghurst J, Akbari A, Watkins A, Paterson J, Jennings D, Lyons RA, Powell HR, Kerr MP, Chin RW, Pickrell WO.
Current and emerging pharmacotherapy for the treatment of Lennox-Gastaut syndrome
Besag FMC, Vasey MJ, Chin RFM.
Current Best Practices for Analysis of Dendritic Spine Morphology and Number in Neurodevelopmental Disorder Research
Li BZ, Sumera A, Booker SA, McCullagh EA.
Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder
Leyhausen J, Schäfer T, Gurr C, Berg LM, Seelemeyer H, Pretzsch CM, Loth E, Oakley B, Buitelaar JK, Beckmann CF, Floris DL, Charman T, Bourgeron T, Banaschewski T, Jones EJH, Tillmann J, Chatham C; EU-AIMS LEAP Group; Murphy DG, Ecker C.
Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2
Davies FCJ, Marshall GF, Pegram E, Gadd D, Abbott CM.
Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals
Kontaxi C, Ivanova D, Davenport EC, Kind PC, Cousin MA.
Epilepsy-related mortality during the COVID-19 pandemic: A nationwide study of routine Scottish data
Mbizvo GK, Schnier C, Ramsay J, Duncan SE, Chin RF.
Evaluation of Digitalisation in Healthcare and the Quantification of the "Unmeasurable"
Cresswell K, Anderson S, Montgomery C, Weir CJ, Atter M, Williams R.
Excessive proteostasis contributes to pathology in fragile X syndrome
Louros SR, Seo SS, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano MA, Muscas M, Verity NC, Wills JC, Li KW, Nolan MF, Osterweil EK.
Functional neurological disorder in children and young people: Incidence, clinical features, and prognosis
Yong K, Chin RFM, Shetty J, Hogg K, Burgess K, Lindsay M, McLellan A, Stone J, KamathTallur K; Edinburgh Paediatric FND Study Group.
Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing
Hocking LJ, Andrews C, Armstrong C, Ansari M, Baty D, Berg J, Bradley T, Clark C, Diamond A, Doherty J, Lampe A, McGowan R, Moore DJ, O'Sullivan D, Purvis A, Santoyo-Lopez J, Westwood P, Abbott M, Williams N; Scottish Genomes Partnership; Aitman TJ, Miedzybrodzka Z.
Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland
Wright CF, Campbell P, Eberhardt RY, Aitken S, Perrett D, Brent S, Danecek P, Gardner EJ, Chundru VK, Lindsay SJ, Andrews K, Hampstead J, Kaplanis J, Samocha KE, Middleton A, Foreman J, Hobson RJ, Parker MJ, Martin HC, FitzPatrick DR, Hurles ME, Firth HV; DDD Study.
How and why to use 'vulnerability': an interdisciplinary analysis of disease risk, indeterminacy and normality
Ford A, De Togni G, Erikainen S, Filipe AM, Pickersgill M, Sturdy S, Swallow J, Young I.
Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion
Yang Y, Booker SA, Clegg JM, Quintana-Urzainqui I, Sumera A, Kozic Z, Dando O, Martin Lorenzo S, Herault Y, Kind PC, Price DJ, Pratt T.
Identifying opportunities for upstream evaluations relevant to child and maternal health: a UK policy-mapping review
Stewart E, Pearce A, Given J, Gilbert R, Brophy S, Cookson R, Hardelid P, Harron KL, Leyland A, Wood R, Dundas R.
LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period
Kozar-Gillan N, Velichkova A, Kanatouris G, Eshed-Eisenbach Y, Steel G, Jaegle M, Aunin E, Peles E, Torsney C, Meijer DN.
Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study
Oblong LM, Llera A, Mei T, Haak K, Isakoglou C, Floris DL, Durston S, Moessnang C, Banaschewski T, Baron-Cohen S, Loth E, Dell'Acqua F, Charman T, Murphy DGM, Ecker C, Buitelaar JK, Beckmann CF; EU-AIMS LEAP Group; Forde NJ.
Longitudinal Invariance of the Strengths and Difficulties Questionnaire Across Ages 4 to 16 in the ALSPAC Sample
Speyer LG, Auyeung B, Murray AL.
Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
Gospodinova KO, Olsen D, Kaas M, Anderson SM, Phillips J, Walker RM, Bermingham ML, Payne AL, Giannopoulos P, Pandya D, Spires-Jones TL, Abbott CM, Porteous DJ, Glerup S, Evans KL.
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1
Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim IS, Kouloulia S, Zafeiri M, Pothos P, Bonneil É, Gantois I, Popic J, Kim SH, Wong C, Cao R, Komiyama NH, Atlasi Y, Jafarnejad SM, Khoutorsky A, Gkogkas CG.
Mortality in children with epilepsy: Cohort study using the clinical practice research datalink
Schnier C, Chin RF.
Novel MECP2 gene therapy is effective in a multicenter study using two mouse models of Rett syndrome and is safe in non-human primates
Powers S, Likhite S, Gadalla KK, Miranda CJ, Huffenberger AJ, Dennys C, Foust KD, Morales P, Pierson CR, Rinaldi F, Perry S, Bolon B, Wein N, Cobb S, Kaspar BK, Meyer KC.
Phosphatidylinositol 4-kinase IIα is a glycogen synthase kinase 3-regulated interaction hub for activity-dependent bulk endocytosis
Blumrich EM, Nicholson-Fish JC, Pronot M, Davenport EC, Kurian D, Cole A, Smillie KJ, Cousin MA.
Pilot study of a ketogenic diet in bipolar disorder
Needham N, Campbell IH, Grossi H, Kamenska I, Rigby BP, Simpson SA, McIntosh E, Bahuguna P, Meadowcroft B, Creasy F, Mitchell-Grigorjeva M, Norrie J, Thompson G, Gibbs MC, McLellan A, Fisher C, Moses T, Burgess K, Brown R, Thrippleton MJ, Campbell H, Smith DJ.
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry
Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, Mahrhold S, Krez N, Cousin MA, Cooper-White R, Cooper-White JJ, Collins BM, Parton RG, Balistreri G, Rummel A, Meunier FA.
Questionnaire-based screening for mental distress in epilepsy: Outline and feasibility of an outpatient screening and intervention pathway
Gillespie DC, Flewitt BI, Sacripante R, Burns V, Young L, Chin RF, Duncan SE.
Regulatory de novo mutations underlying intellectual disability
De Vas MG, Boulet F, Joshi SS, Garstang MG, Khan TN, Atla G, Parry D, Moore D, Cebola I, Zhang S, Cui W, Lampe AK, Lam WW; Genomics England Research Consortium; Ferrer J, Pradeepa MM, Atanur SS.
Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy
Bonnycastle K, Dobson KL, Blumrich EM, Gajbhiye A, Davenport EC, Pronot M, Steinruecke M, Trost M, Gonzalez-Sulser A, Cousin MA.
Review of the new APLS guideline (2022): Management of the convulsing child
Bacon M, Appleton R, Bangalore H, Brand C, Browning J, Chin RF, Mahal S, Saranga Estevan S, McHale K, McLellan A, Milne N, Pujar S, Rao T, Short S, Warriner S, Yoong M.
Screening for anxiety, depression and suicidality by epilepsy specialists in adult services in Scotland
Gillespie DC, Duncan SE, Flewitt BI, Sacripante R, Chin RF.
Stalling or oiling the engines of diagnosis? Shifting perspectives on the DSM and categorical diagnosis in psychiatry
Martyn Pickersgill
Study protocol: examining the impacts of COVID-19 mitigation measures on pregnancy and birth outcomes in Scotland-a linked administrative data study
Oberndorfer M, Henery PM, Dundas R, Leyland AH, Paranjothy S, Stock SJ, Wood R, Nelson SM, Kearns R, Pearce A.
The association of structural connectome efficiency with cognition in children with epilepsy
Woodfield J, Chin RFM, van Schooneveld MMJ, van den Heuvel M, Bastin ME, Braun KPJ.
The effect of metacognitive executive function training on children's executive function, proactive control, and academic skills
Kubota M, Hadley LV, Schaeffner S, Könen T, Meaney JA, Morey CC, Auyeung B, Moriguchi Y, Karbach J, Chevalier N.
The Impact of COVID-19 Restrictions on Psychological Distress in Family Caregivers of Children with Neurodevelopmental Disability in the UK
Gillespie-Smith K, McConachie D, Ballantyne C, Auyeung B, Goodall K.
The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings
Berg LM, Gurr C, Leyhausen J, Seelemeyer H, Bletsch A, Schaefer T, Pretzsch CM, Oakley B, Loth E, Floris DL, Buitelaar JK, Beckmann CF, Banaschewski T, Charman T, Jones EJH, Tillmann J, Chatham CH, Bourgeron T; EU-AIMS LEAP Group; Murphy DG, Ecker C.
The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis
Kontaxi C, Kim N, Cousin MA.
Using Critical Success Index or Gilbert Skill Score as composite measures of positive predictive value and sensitivity in diagnostic accuracy studies: Weather forecasting informing epilepsy research
Mbizvo GK, Bennett KH, Simpson CR, Duncan SE, Chin RFM, Larner AJ.
A brain atlas of synapse protein lifetime across the mouse lifespan
Bulovaite E, Qiu Z, Kratschke M, Zgraj A, Fricker DG, Tuck EJ, Gokhale R, Koniaris B, Jami SA, Merino-Serrais P, Husi E, Mendive-Tapia L, Vendrell M, O'Dell TJ, DeFelipe J, Komiyama NH, Holtmaat A, Fransén E, Grant SGN.
A functional MRI facial emotion-processing study of autism in individuals with special educational needs
McKechanie AG, Lawrie SM, Whalley HC, Stanfield AC.
A novel synaptopathy-defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia
Clayton EL, Bonnycastle K, Isaacs AM, Cousin MA, Schorge S.
A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection
Calvert C, Carruthers J, Denny C, Donaghy J, Hillman S, Hopcroft LEM, Hopkins L, Goulding A, Lindsay L, McLaughlin T, Moore E, Pan J, Taylor B, Almaghrabi F, Auyeung B, Bhaskaran K, Gibbons CL, Katikireddi SV, McCowan C, Murray J, O'Leary M, Ritchie LD, Shah SA, Simpson CR, Robertson C, Sheikh A, Stock SJ, Wood R.
A symptom level perspective on reactive and proactive aggressive behaviours and ADHD symptoms in childhood
Speyer LG, Eisner M, Ribeaud D, Luciano M, Auyeung B, Murray AL.
Abnormal brain state distribution and network connectivity in a SYNGAP1 rat model
Buller-Peralta I, Maicas-Royo J, Lu Z, Till SM, Wood ER, Kind PC, Escudero J, Gonzalez-Sulser A.
Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study
Wagstyl K, Whitaker K, Raznahan A, Seidlitz J, Vértes PE, Foldes S, Humphreys Z, Hu W, Mo J, Likeman M, Davies S, Lenge M, Cohen NT, Tang Y, Wang S, Ripart M, Chari A, Tisdall M, Bargallo N, Conde-Blanco E, Pariente JC, Pascual-Diaz S, Delgado-Martínez I, Pérez-Enríquez C, Lagorio I, Abela E, Mullatti N, O'Muircheartaigh J, Vecchiato K, Liu Y, Caligiuri M, Sinclair B, Vivash L, Willard A, Kandasamy J, McLellan A, Sokol D, Semmelroch M, Kloster A, Opheim G, Yasuda C, Zhang K, Hamandi K, Barba C, Guerrini R, Gaillard WD, You X, Wang I, González-Ortiz S, Severino M, Striano P, Tortora D, Kalviainen R, Gambardella A, Labate A, Desmond P, Lui E, O'Brien T, Shetty J, Jackson G, Duncan JS, Winston GP, Pinborg L, Cendes F, Cross JH, Baldeweg T, Adler S.
Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology
Mei T, Forde NJ, Floris DL, Dell'Acqua F, Stones R, Ilioska I, Durston S, Moessnang C, Banaschewski T, Holt RJ, Baron-Cohen S, Rausch A, Loth E, Oakley B, Charman T, Ecker C, Murphy DGM; EU-AIMS LEAP group; Beckmann CF, Llera A, Buitelaar JK.
BNT162b2 COVID-19 vaccination uptake, safety, effectiveness and waning in children and young people aged 12-17 years in Scotland
Rudan I, Millington T, Antal K, Grange Z, Fenton L, Sullivan C, Buelo A, Wood R, Woolford L, Swann OV, Murray JLK, Cullen LA, Moore E, Haider F, Almaghrabi F, McMenamin J, Agrawal U, Shah SA, Kerr S, Simpson CR, Katikireddi SV, Ritchie SLD, Robertson C, Sheikh SA.
Brain charts for the human lifespan
Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford SA, Benegal V, Beyer F, Blangero J, Blesa Cábez M, Boardman JP, Borzage M, Bosch-Bayard JF, Bourke N, Calhoun VD, Chakravarty MM, Chen C, Chertavian C, Chetelat G, Chong YS, Cole JH, Corvin A, Costantino M, Courchesne E, Crivello F, Cropley VL, Crosbie J, Crossley N, Delarue M, Delorme R, Desrivieres S, Devenyi GA, Di Biase MA, Dolan R, Donald KA, Donohoe G, Dunlop K, Edwards AD, Elison JT, Ellis CT, Elman JA, Eyler L, Fair DA, Feczko E, Fletcher PC, Fonagy P, Franz CE, Galan-Garcia L, Gholipour A, Giedd J, Gilmore JH, Glahn DC, Goodyer IM, Grant PE, Groenewold NA, Gunning FM, Gur RE, Gur RC, Hammill CF, Hansson O, Hedden T, Heinz A, Henson RN, Heuer K, Hoare J, Holla B, Holmes AJ, Holt R, Huang H, Im K, Ipser J, Jack CR Jr, Jackowski AP, Jia T, Johnson KA, Jones PB, Jones DT, Kahn RS, Karlsson H, Karlsson L, Kawashima R, Kelley EA, Kern S, Kim KW, Kitzbichler MG, Kremen WS, Lalonde F, Landeau B, et al.
Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test
Garcia-Font N, Mitchell-Heggs R, Saxena K, Gabbert C, Taylor G, Mastroberadino G, Spooner PA, Gobbo F, Dabrowska JK, Chattarji S, Kind PC, Schultz SR, Morris RGM.
Clinical and behavioural features of SYNGAP1-related intellectual disability: a parent and caregiver description
Wright D, Kenny A, Eley S, McKechanie AG, Stanfield AC.
Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
Zlatic SA, Duong D, Gadalla KKE, Murage B, Ping L, Shah R, Fink JJ, Khwaja O, Swanson LC, Sahin M, Rayaprolu S, Kumar P, Rangaraju S, Bird A, Tarquinio D, Carpenter R, Cobb S, Faundez V.
Creation and evaluation of full-text literature-derived, feature-weighted disease models of genetically determined developmental disorders
T.M Yates, A. Lain, J. Campbell, D.R. FitzPatrick, T.I. Simpson.
Cross-species considerations in models of neurodevelopmental disorders
Till SM, Hickson RDL, Kind PC.
Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy
Stevering CH, Lamberink HJ, Woodfield J, van Schooneveld M, Otte WM, Chin RFM, Bastin ME, Geleijns K, Braun KPJ.
Current recommendations/practices for anonymising data from clinical trials in order to make it available for sharing: A scoping review
Rodriguez A, Tuck C, Dozier MF, Lewis SC, Eldridge S, Jackson T, Murray A, Weir CJ.
Dynamin is primed at endocytic sites for ultrafast endocytosis
Imoto Y, Raychaudhuri S, Ma Y, Fenske P, Sandoval E, Itoh K, Blumrich EM, Matsubayashi HT, Mamer L, Zarebidaki F, Söhl-Kielczynski B, Trimbuch T, Nayak S, Iwasa JH, Liu J, Wu B, Ha T, Inoue T, Jorgensen EM, Cousin MA, Rosenmund C, Watanabe S
EEG as a translational biomarker and outcome measure in fragile X syndrome
Kenny A, Wright D, Stanfield AC.
Emerging Therapeutic Strategies for Fragile X Syndrome: Q&A
Alusi G, Berry-Kravis E, Nelson D, Orefice LL, Booker SA.
Empathizing, systemizing, empathizing-systemizing difference and their association with autistic traits in children with autism spectrum disorder, with and without intellectual disability
Pan N, Auyeung B, Wang X, Lin LZ, Li HL, Zhan XL, Jin CK, Jing J, Li XH.
Empathy, Theory of Mind, and Prosocial Behaviors in Autistic Children
Wang X, Auyeung B, Pan N, Lin LZ, Chen Q, Chen JJ, Liu SY, Dai MX, Gong JH, Li XH, Jing J.
Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome
Seo SS, Louros SR, Anstey N, Gonzalez-Lozano MA, Harper CB, Verity NC, Dando O, Thomson SR, Darnell JC, Kind PC, Li KW, Osterweil EK.
Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome
Asiminas A, Booker SA, Dando OR, Kozic Z, Arkell D, Inkpen FH, Sumera A, Akyel I, Kind PC, Wood ER.
Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1
Vandrey B, Armstrong J, Brown CM, Garden DLF, Nolan MF.
FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis
Bonnycastle K, Kind PC, Cousin MA.
Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3(-/y) rat model of autism
Anstey NJ, Kapgal V, Tiwari S, Watson TC, Toft AKH, Dando OR, Inkpen FH, Baxter PS, Kozić Z, Jackson AD, He X, Nawaz MS, Kayenaat A, Bhattacharya A, Wyllie DJA, Chattarji S, Wood ER, Hardt O, Kind PC.
Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study
McTaggart S, MacColl G, Gronkowski K, Wood R, Leach JP, Bennie M.
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study
Spitzer H, Ripart M, Whitaker K, D'Arco F, Mankad K, Chen AA, Napolitano A, De Palma L, De Benedictis A, Foldes S, Humphreys Z, Zhang K, Hu W, Mo J, Likeman M, Davies S, Güttler C, Lenge M, Cohen NT, Tang Y, Wang S, Chari A, Tisdall M, Bargallo N, Conde-Blanco E, Pariente JC, Pascual-Diaz S, Delgado-Martínez I, Pérez-Enríquez C, Lagorio I, Abela E, Mullatti N, O'Muircheartaigh J, Vecchiato K, Liu Y, Caligiuri ME, Sinclair B, Vivash L, Willard A, Kandasamy J, McLellan A, Sokol D, Semmelroch M, Kloster AG, Opheim G, Ribeiro L, Yasuda C, Rossi-Espagnet C, Hamandi K, Tietze A, Barba C, Guerrini R, Gaillard WD, You X, Wang I, González-Ortiz S, Severino M, Striano P, Tortora D, Kälviäinen R, Gambardella A, Labate A, Desmond P, Lui E, O'Brien T, Shetty J, Jackson G, Duncan JS, Winston GP, Pinborg LH, Cendes F, Theis FJ, Shinohara RT, Cross JH, Baldeweg T, Adler S, Wagstyl K.
Ionotropic glutamate receptors: structure, function and dysfunction
Wyllie DJA, Bowie D.
Is there an association between prenatal testosterone and autistic traits in adolescents?.
Dooley N, Ruigrok A, Holt R, Allison C, Tsompanidis A, Waldman J, Auyeung B, Lombardo MV, Baron-Cohen S.
Maternal infections during pregnancy and child cognitive outcomes.
Kwok J, Hall HA, Murray AL, Lombardo MV, Auyeung B.
Networks Underlie Temporal Onset of Dysplasia-Related Epilepsy: A MELD Study.
Cohen NT, You X, Krishnamurthy M, Sepeta LN, Zhang A, Oluigbo C, Whitehead MT, Gholipour T, Baldeweg T, Wagstyl K, Adler S, Gaillard WD; Multi-Centre Epilepsy Lesion Detection (MELD) Project.
New inroads into the brain circuits and network dynamics behind sudden unexpected death in epilepsy.
Gonzalez-Sulser A.
NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease
Haddow K, Kind PC, Hardingham GE.
NREM Sleep Parasomnias Commencing in Childhood: Trauma and Atopy as Perpetuating Factors
Walsh C, Mitchell L, Hrozanova M, Kotoulas SC, Derry C, Morrison I, Riha RL
Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project
Looden T, Floris DL, Llera A, Chauvin RJ, Charman T, Banaschewski T, Murphy D, Marquand AF, Buitelaar JK, Beckmann CF; AIMS-2-TRIALS group.
Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort
Speyer LG, Neaves S, Hall HA, Hemani G, Lombardo MV, Murray AL, Auyeung B, Luciano M.
Practical guidance for planning resources required to support publicly-funded adaptive clinical trials
Wason JMS, Dimairo M, Biggs K, Bowden S, Brown J, Flight L, Hall J, Jaki T, Lowe R, Pallmann P, Pilling MA, Snowdon C, Sydes MR, Villar SS, Weir CJ, Wilson N, Yap C, Hancock H, Maier R.
Prevalence and healthcare resource utilization of patients with Dravet syndrome: Retrospective linkage cohort study
Owen Pickrell W, Guelfucci F, Martin M, Holland R, Chin RFM..
Quantitative detection of seizures with minimal-density EEG montage using phase synchrony and cross-channel coherence amplitude in critical care
Abdullateef S, Jordan B, Rae V, McLellan A, Escudero J, Nenadovic V, Lo T.
Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis
Garcés P, Baumeister S, Mason L, Chatham CH, Holiga S, Dukart J, Jones EJH, Banaschewski T, Baron-Cohen S, Bölte S, Buitelaar JK, Durston S, Oranje B, Persico AM, Beckmann CF, Bougeron T, Dell'Acqua F, Ecker C, Moessnang C, Charman T, Tillmann J, Murphy DGM, Johnson M, Loth E, Brandeis D, Hipp JF; EU-AIMS LEAP group authorship.
SFARI genes and where to find them; modelling Autism Spectrum Disorder specific gene expression dysregulation with RNA-seq data
Magdalena Navarro Torres Arpi, T. Ian Simpson
Single Photon Kilohertz Frame Rate Imaging of Neural Activity
Tian T, Yuan Y, Mitra S, Gyongy I, Nolan MF.
Spatial representation by ramping activity of neurons in the retrohippocampal cortex
Tennant SA, Clark H, Hawes I, Tam WK, Hua J, Yang W, Gerlei KZ, Wood ER, Nolan MF.
Stimulant and non-stimulant drug therapy for people with attention deficit hyperactivity disorder and epilepsy
Eaton C, Yong K, Walter V, Mbizvo GK, Rhodes S, Chin RF.
Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function
Ivanova D, Cousin MA.
Uptake of infant and preschool immunisations in Scotland and England during the COVID-19 pandemic: An observational study of routinely collected data
McQuaid F, Mulholland R, Sangpang Rai Y, Agrawal U, Bedford H, Cameron JC, Gibbons C, Roy P, Sheikh A, Shi T, Simpson CR, Tait J, Tessier E, Turner S, Villacampa Ortega J, White J, Wood R.
14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice
Yokoi N, Fukata Y, Okatsu K, Yamagata A, Liu Y, Sanbo M, Miyazaki Y, Goto T, Abe M, Kassai H, Sakimura K, Meijer D, Hirabayashi M, Fukai S, Fukata M.
21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans
Watkins JC, Evans RH, Bayés À, Booker SA, Gibb A, Mabb AM, Mayer M, Mellor JR, Molnár E, Niu L, Ortega A, Pankratov Y, Ramos-Vicente D, Rodríguez-Campuzano A, Rodríguez-Moreno A, Wang LY, Wang YT, Wollmuth L, Wyllie DJA, Zhuo M, Frenguelli BG..
A consideration of the social dimensions and implications of neuroimaging research in global health, as related to the theory-ladened and theory-generating aspects of technology.
Pickersgill M.
A Differential Effect of Lovastatin versus Simvastatin in Neurodevelopmental Disorders.
Muscas M, Seo SS, Louros SR, Osterweil EK.
A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage.
Bernal J, Valdés-Hernández MDC, Escudero J, Heye AK, Sakka E, Armitage PA, Makin S, Touyz RM, Wardlaw JM, Thrippleton MJ.
A unified resource and configurable model of the synapse proteome and its role in disease.
Alexithymia and Autistic Traits as Contributing Factors to Empathy Difficulties in Preadolescent Children.
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction.
Perkins EM, Burr K, Banerjee P, Mehta AR, Dando O, Selvaraj BT, Suminaite D, Nanda J, Henstridge CM, Gillingwater TH, Hardingham GE, Wyllie DJA, Chandran S, Livesey MR.
Are you tuned in? The challenges of seizure identification in children with intellectual disability - A potential for video-based care-pathway.
Hutchison M, Buxton G, Brand C, McLellan A, Shetty J.
Assessment of Outliers and Detection of Artifactual Network Segments Using Univariate and Multivariate Dispersion Entropy on Physiological Signals.
Kafantaris E, Piper I, Lo TM, Escudero J.
Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
CDKL5 deficiency disorder: a pathophysiology of neural maintenance
Kind PC, Bird A.
Children's understanding of epilepsy: A qualitative study.
Harden J, Black R, Pickersgill M, Shetty J, McLellan A, Brand C, Small M, McDonnell J, Clarke L, Chin RF.
Cohort Profile: Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) Database
Mulholland RH, Vasileiou E, Simpson CR, Robertson C, Ritchie LD, Agrawal U, Woolhouse M, Murray JL, Stagg HR, Docherty AB, McCowan C, Wood R, Stock SJ, Sheikh A.
Contribution of NMDA Receptors to Synaptic Function in Rat Hippocampal Interneurons
Booker SA, Sumera A, Kind PC, Wyllie DJA.
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA.
Correction of amygdalar dysfunction in a rat model of fragile X syndrome
Fernandes G, Mishra PK, Nawaz MS, Donlin-Asp PG, Rahman MM, Hazra A, Kedia S, Kayenaat A, Songara D, Wyllie DJA, Schuman EM, Kind PC, Chattarji S.
COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort study
Agrawal U, Katikireddi SV, McCowan C, Mulholland RH, Azcoaga-Lorenzo A, Amele S, Fagbamigbe AF, Vasileiou E, Grange Z, Shi T, Kerr S, Moore E, Murray JLK, Shah SA, Ritchie L, O'Reilly D, Stock SJ, Beggs J, Chuter A, Torabi F, Akbari A, Bedston S, McMenamin J, Wood R, Tang RSM, de Lusignan S, Hobbs FDR, Woolhouse M, Simpson CR, Robertson C, Sheikh A.
Current molecular approaches to investigate pre-synaptic dysfunction.
Harper CB, Smillie KJ.
Deep entorhinal cortex: from circuit organization to spatial cognition and memory.
Gerlei KZ, Brown CM, Sürmeli G, Nolan MF.
Deep Learning of resting-state electroencephalogram signals for 3-class classification of Alzheimer's Disease, Mild Cognitive Impairment and Healthy Ageing.
Huggins CJ, Escudero J, Parra MA, Scally B, Anghinah R, Vitória Lacerda de Araújo A, Basile LF, Abasolo D.
Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants
Symonds JD, Elliott KS, Shetty J, Armstrong M, Brunklaus A, Cutcutache I, Diver LA, Dorris L, Gardiner S, Jollands A, Joss S, Kirkpatrick M, McLellan A, MacLeod S, O'Regan M, Page M, Pilley E, Pilz DT, Stephen E, Stewart K, Ashrafian H, Knight JC, Zuberi SM.
Effect of Vaccination on Transmission of SARS-CoV-2
Shah ASV, Gribben C, Bishop J, Hanlon P, Caldwell D, Wood R, Reid M, McMenamin J, Goldberg D, Stockton D, Hutchinson S, Robertson C, McKeigue PM, Colhoun HM, McAllister DA.
Epidemiology and outcome of status epilepticus in children: a Scottish population cohort study.
Mitchell C, Chatterton Dickson L, Ramsay A, Mesalles-Naranjo O, Leonard P, Brand C, Mclellan A, Shetty J.
Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases
Milosevic I, Cousin MA.
Glutamate and functional connectivity - support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders.
Siegel-Ramsay JE, Romaniuk L, Whalley HC, Roberts N, Branigan H, Stanfield AC, Lawrie SM, Dauvermann MR.
Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability
Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy LC, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Roest Crollius H, FitzPatrick DR.
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.
Bertelsen N, Landi I, Bethlehem RAI, Seidlitz J, Busuoli EM, Mandelli V, Satta E, Trakoshis S, Auyeung B, Kundu P, Loth E, Dumas G, Baumeister S, Beckmann CF, Bölte S, Bourgeron T, Charman T, Durston S, Ecker C, Holt RJ, Johnson MH, Jones EJH, Mason L, Meyer-Lindenberg A, Moessnang C, Oldehinkel M, Persico AM, Tillmann J, Williams SCR, Spooren W, Murphy DGM, Buitelaar JK; EU-AIMS LEAP group, Baron-Cohen S, Lai MC, Lombardo MV.
Impact of Visual Design Elements and Principles in Human Electroencephalogram Brain Activity Assessed with Spectral Methods and Convolutional Neural Networks
Cabrera FE, Sánchez-Núñez P, Vaccaro G, Peláez JI, Escudero J.
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
Horner AE, Norris RH, McLaren-Jones R, Alexander L, Komiyama NH, Grant SGN, Nithianantharajah J, Kopanitsa MV.
Links between perinatal risk factors and maternal psychological distress: A network analysis.
Speyer LG, Hall HA, Ushakova A, Murray AL, Luciano M, Auyeung B.
Longitudinal effects of breast feeding on parent-reported child behaviour.
Speyer LG, Hall HA, Ushakova A, Murray AL, Luciano M, Auyeung B.
Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.
Hristova K, Martinez-Gonzalez C, Watson TC, Codadu NK, Hashemi K, Kind PC, Nolan MF, Gonzalez-Sulser A.
Modelling epilepsy in the mouse: challenges and solutions.
Marshall GF, Gonzalez-Sulser A, Abbott CM.
Monitoring Activity-Dependent Bulk Endocytosis in Primary Neuronal Culture Using Large Fluorescent Dextrans.
Cousin MA, Smillie KJ.
NMDA receptor function in inhibitory neurons.
Booker SA, Wyllie DJA.
Pilot project of psychological services integrated into a pediatric epilepsy clinic: Psychology Adding Value - Epilepsy Screening (PAVES).
George C, Felix SA, McLellan A, Shetty J, Middleton J, Chin RF, Poveda B, Brand C, Small M, Verity K.
Preface to the Special Issue "Presynaptic Dysfunction and Disease".
Smillie KJ, Cousin MA, Gordon SL.
Prenatal Maternal Infections and Children's Neurodevelopment in the UK Millennium Cohort Study: A Focus on ASD and ADHD.
Hall HA, Speyer LG, Murray AL, Auyeung B.
Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle.
Bonnycastle K, Davenport EC, Cousin MA.
Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors
Subrahmanyam R, Dwivedi D, Rashid Z, Bonnycastle K, Cousin MA, Chattarji S.
Repeated whole-cell patch-clamp recording from CA1 pyramidal cells in rodent hippocampal slices followed by axon initial segment labeling
Oliveira LS, Sumera A, Booker SA
Sleep Abnormalities in the Synaptopathies-SYNGAP1-Related Intellectual Disability and Phelan-McDermid Syndrome
Smith-Hicks C, Wright D, Kenny A, Stowe RC, McCormack M, Stanfield AC, Holder JL Jr.
Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review.
Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L.
Synaptophysin controls synaptobrevin-II retrieval via a cryptic C-terminal interaction site.
Harper CB, Blumrich EM, Cousin MA.
Synaptophysin-dependent synaptobrevin-2 trafficking at the presynapse-Mechanism and function
Cousin MA.
The contribution of X-linked coding variation to severe developmental disorders.
Martin HC, Gardner EJ, Samocha KE, Kaplanis J, Akawi N, Sifrim A, Eberhardt RY, Tavares ALT, Neville MDC, Niemi MEK, Gallone G, McRae J; Deciphering Developmental Disorders Study, Wright CF, FitzPatrick DR, Firth HV, Hurles ME.
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators.
The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators.
The UK experience of stereoelectroencephalography in children: An analysis of factors predicting the identification of a seizure-onset zone and subsequent seizure freedom
UK Children’s Epilepsy Surgery Collaboration
A brainwide atlas of synapses across the mouse life span.
Cizeron M, Qiu Z, Koniaris B, Gokhale R, Komiyama NH, Fransén E, Grant SGN.
A clinical evaluation of a novel algorithm in the reliable detection of epileptic seizures.
Brotherstone R, McLellan A, Graham C, Fisher K.
A nationwide, retrospective, data-linkage, cohort study of epilepsy and incident dementia.
Schnier C, Duncan S, Wilkinson T, Mbizvo GK, Chin RFM.
A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB.
Accuracy of identifying incident stroke cases from linked health care data in UK Biobank.
Rannikmäe K, Ngoh K, Bush K, Al-Shahi Salman R, Doubal F, Flaig R, Henshall DE, Hutchison A, Nolan J, Osborne S, Samarasekera N, Schnier C, Whiteley W, Wilkinson T, Wilson K, Woodfield R, Zhang Q, Allen N, Sudlow CLM.
Adults with epilepsy appear to differ from children in regard to daytime sleepiness.
Urquhart DS, Hill EA, Hill LE, Carruthers E, McLellan AE, Chin R, Shetty J.
An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking.
Harper CB, Small C, Davenport EC, Low DW, Smillie KJ, Martínez-Mármol R, Meunier FA, Cousin MA.
Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease.
Bernal J, Valdés-Hernández MDC, Escudero J, Viksne L, Heye AK, Armitage PA, Makin S, Touyz RM, Wardlaw JM.
Augmentation of Dispersion Entropy for Handling Missing and Outlier Samples in Physiological Signal Monitoring.
Kafantaris E, Piper I, Lo TM, Escudero J.
Bilingualism in autism: Language learning profiles and social experiences.
Digard BG, Sorace A, Stanfield A, Fletcher-Watson S.
Categorical and Dimensional Approaches to Examining the Joint Effect of Autism and Schizotypal Personality Disorder on Sustained Attention.
Abu-Akel A, Philip RCM, Lawrie SM, Johnstone EC, Stanfield AC.
Cell-type-specific visualisation and biochemical isolation of endogenous synaptic proteins in mice.
Zhu F, Collins MO, Harmse J, Choudhary JS, Grant SGN, Komiyama NH.
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.
Brown R, Lam AD, Gonzalez-Sulser A, Ying A, Jones M, Chou RC, Tzioras M, Jordan CY, Jedrasiak-Cape I, Hemonnot AL, Abou Jaoude M, Cole AJ, Cash SS, Saito T, Saido T, Ribchester RR, Hashemi K, Oren I.
Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial.
Goldstein LH, Robinson EJ, Mellers JDC, Stone J, Carson A, Reuber M, Medford N, McCrone P, Murray J, Richardson MP, Pilecka I, Eastwood C, Moore M, Mosweu I, Perdue I, Landau S, Chalder T; CODES study group.
Consistent use of proactive control and relation with academic achievement in childhood.
Kubota M, Hadley LV, Schaeffner S, Könen T, Meaney JA, Auyeung B, Morey CC, Karbach J, Chevalier N.
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA.
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A.
Current understanding of febrile seizures and their long-term outcomes.
Mewasingh LD, Chin RFM, Scott RC.
Disrupted inhibition may give clues in understanding neurodevelopmental disorders.
Cobb SR.
Early diagnosis of Alzheimer's disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts.
Rossini PM, Di Iorio R, Vecchio F, Anfossi M, Babiloni C, Bozzali M, Bruni AC, Cappa SF, Escudero J, Fraga FJ, Giannakopoulos P, Guntekin B, Logroscino G, Marra C, Miraglia F, Panza F, Tecchio F, Pascual-Leone A, Dubois B.
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Duman M, Vaquié A, Nocera G, Heller M, Stumpe M, Siva Sankar D, Dengjel J, Meijer D, Yamaguchi T, Matthias P, Zeis T, Schaeren-Wiemers N, Hayoz A, Ruff S, Jacob C.
Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women.
Procyshyn TL, Lombardo MV, Lai MC, Auyeung B, Crockford SK, Deakin J, Soubramanian S, Sule A, Baron-Cohen S, Bethlehem RAI.
Epilepsy deaths: Learning from health service delivery and trying to reduce risk.
Morrish P, Duncan S, Cock H.
Evaluating improvement interventions using routine data to support a learning health system: research design, data access, analysis and reporting.
Weir CJ, Heazell AEP, Whyte S, Norman JE.
Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes.
Ensor H, Weir CJ.
Evidence for 28 genetic disorders discovered by combining healthcare and research data.
Kaplanis J, Samocha KE, Wiel L, Zhang Z, Arvai KJ, Eberhardt RY, Gallone G, Lelieveld SH, Martin HC, McRae JF, Short PJ, Torene RI, de Boer E, Danecek P, Gardner EJ, Huang N, Lord J, Martincorena I, Pfundt R, Reijnders MRF, Yeung A, Yntema HG; Deciphering Developmental Disorders Study, Vissers LELM, Juusola J, Wright CF, Brunner HG, Firth HV, FitzPatrick DR, Barrett JC, Hurles ME, Gilissen C, Retterer K.
External rewards and positive stimuli promote different cognitive control engagement strategies in children.
Jin X, Auyeung B, Chevalier N.
Facilitating individuals and families affected by fragile X syndrome to participate in medication trials.
Eley SEA, McKechanie AG, Campbell S, Stanfield AC.
Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory.
Vandrey B, Garden DLF, Ambrozova V, McClure C, Nolan MF, Ainge JA.
Foetal oestrogens and autism.
Baron-Cohen S, Tsompanidis A, Auyeung B, Nørgaard-Pedersen B, Hougaard DM, Abdallah M, Cohen A, Pohl A.
Grid cells are modulated by local head direction.
Gerlei K, Passlack J, Hawes I, Vandrey B, Stevens H, Papastathopoulos I, Nolan MF.
Ictal asystole - a letter within a letter.
Mbizvo GK, Derry C, Davenport R.
Incidence of early-onset epilepsy: A prospective population-based study.
Hunter MB, Yoong M, Sumpter RE, Verity K, Shetty J, McLellan A, Chin RFM.
Inhibition of Piezo1 attenuates demyelination in the central nervous system.
Velasco-Estevez M, Gadalla KKE, Liñan-Barba N, Cobb S, Dev KK, Sheridan GK.
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.
Booker SA, Simões de Oliveira L, Anstey NJ, Kozic Z, Dando OR, Jackson AD, Baxter PS, Isom LL, Sherman DL, Hardingham GE, Brophy PJ, Wyllie DJA, Kind PC.
Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex.
Pastoll H, Garden DL, Papastathopoulos I, Sürmeli G, Nolan MF.
IQ and Internalising Symptoms in Adolescents with ASD.
Edirisooriya M, Dykiert D, Auyeung B.
Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease.
McAdam RL, Morton A, Gordon SL, Alterman JF, Khvorova A, Cousin MA, Smillie KJ.
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
Hulme H, Meikle LM, Strittmatter N, van der Hooft JJJ, Swales J, Bragg RA, Villar VH, Ormsby MJ, Barnes S, Brown SL, Dexter A, Kamat MT, Komen JC, Walker D, Milling S, Osterweil EK, MacDonald AS, Schofield CJ, Tardito S, Bunch J, Douce G, Edgar JM, Edrada-Ebel R, Goodwin RJA, Burchmore R, Wall DM.
Neurobiological limits and the somatic significance of love: Caregivers' engagements with neuroscience in Scottish parenting programmes.
Broer T, Pickersgill M, Cunningham-Burley S.
Neuronal antibody prevalence in children with seizures under 3 years: A prospective national cohort.
Symonds JD, Moloney TC, Lang B, McLellan A, O'Regan ME, MacLeod S, Jollands A, Vincent A, Kirkpatrick M, Brunklaus A, Shetty J, Dorris L, Forbes K, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Findlay C, Grattan R, MacDonnell J, McKnight J, Morrison CA, Nairn L, Pilley E, Stephen E, Thomsen S, Webb A, Wilson M, Zuberi SM.
Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.
Parker RA, Weir CJ.
Normalised degree variance.
Smith KM, Escudero J.
Phenotypic impacts of CSF1R deficiencies in humans and model organisms.
Hume DA, Caruso M, Ferrari-Cestari M, Summers KM, Pridans C, Irvine KM.
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Yong XLH, Cousin MA, Anggono V.
Prenatal maternal infections and children's socioemotional development: findings from the UK Millennium Cohort Study.
Hall HA, Speyer LG, Murray AL, Auyeung B.
Proof-of-concept for a gene replacement approach to CDKL5 deficiency disorder.
Benke TA, Kind PC.
Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort.
Goldstein LH, Robinson EJ, Mellers JDC, Stone J, Carson A, Chalder T, Reuber M, Eastwood C, Landau S, McCrone P, Moore M, Mosweu I, Murray J, Perdue I, Pilecka I, Richardson MP, Medford N; CODES Study Group; CODES study group.
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Davies FCJ, Hope JE, McLachlan F, Marshall GF, Kaminioti-Dumont L, Qarkaxhija V, Nunez F, Dando O, Smith C, Wood E, MacDonald J, Hardt O, Abbott CM.
Reciprocal Developmental Relations Between ADHD and Anxiety in Adolescence: A Within-Person Longitudinal Analysis of Commonly Co-Occurring Symptoms.
Murray AL, Caye A, McKenzie K, Auyeung B, Murray G, Ribeaud D, Freeston M, Eisner M.
Rodent genetic models of neurodevelopmental disorders and epilepsy.
Gonzalez-Sulser A.
Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome.
Wong H, Hooper AWM, Niibori Y, Lee SJ, Hategan LA, Zhang L, Karumuthil-Melethil S, Till SM, Kind PC, Danos O, Bruder JT, Hampson DR.
Social cognition in adults with autism spectrum disorders: Validation of the Edinburgh Social Cognition Test (ESCoT).
Baksh RA, Abrahams S, Bertlich M, Cameron R, Jany S, Dorrian T, Baron-Cohen S, Allison C, Smith P, MacPherson SE, Auyeung B.
Species-Specificity of Transcriptional Regulation and the Response to Lipopolysaccharide in Mammalian Macrophages.
Bush SJ, McCulloch MEB, Lisowski ZM, Muriuki C, Clark EL, Young R, Pridans C, Prendergast JGD, Summers KM, Hume DA.
Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: A European Academy of Neurology, European Sleep Research Society and International League against Epilepsy-Europe consensus review.
Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L.
Subcortical nuclei volumes are associated with cognition in children post-convulsive status epilepticus: Results at nine years follow-up.
Bennett KH, Pujar SS, Martinos MM, Clark CA, Yoong M, Scott RC, Chin RFM.
Temporal trends in incidence of Rolandic epilepsy, prevalence of comorbidities and prescribing trends: birth cohort study.
Stephen J, Weir CJ, Chin RF.
The accuracy of using administrative healthcare data to identify epilepsy cases: A systematic review of validation studies.
Mbizvo GK, Bennett KH, Schnier C, Simpson CR, Duncan SE, Chin RFM.
The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.
Dimairo M, Pallmann P, Wason J, Todd S, Jaki T, Julious SA, Mander AP, Weir CJ, Koenig F, Walton MK, Nicholl JP, Coates E, Biggs K, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG; ACE Consensus Group.
The association between analgesic drug use in pregnancy and neurodevelopmental disorders: protocol for an umbrella review.
Kwok J, Hall HA, Murray AL, Auyeung B.
The Dementias Platform UK (DPUK) Data Portal.
Bauermeister S, Orton C, Thompson S, Barker RA, Bauermeister JR, Ben-Shlomo Y, Brayne C, Burn D, Campbell A, Calvin C, Chandran S, Chaturvedi N, Chêne G, Chessell IP, Corbett A, Davis DHJ, Denis M, Dufouil C, Elliott P, Fox N, Hill D, Hofer SM, Hu MT, Jindra C, Kee F, Kim CH, Kim C, Kivimaki M, Koychev I, Lawson RA, Linden GJ, Lyons RA, Mackay C, Matthews PM, McGuiness B, Middleton L, Moody C, Moore K, Na DL, O'Brien JT, Ourselin S, Paranjothy S, Park KS, Porteous DJ, Richards M, Ritchie CW, Rohrer JD, Rossor MN, Rowe JB, Scahill R, Schnier C, Schott JM, Seo SW, South M, Steptoe M, Tabrizi SJ, Tales A, Tillin T, Timpson NJ, Toga AW, Visser PJ, Wade-Martins R, Wilkinson T, Williams J, Wong A, Gallacher JEJ.
The never-changing face of fragile X?
McKechanie AG, Lawrie SM, Stanfield AC.
The Secure Anonymised Information Linkage databank Dementia e-cohort (SAIL-DeC).
Schnier C, Wilkinson T, Akbari A, Orton C, Sleegers K, Gallacher J, Lyons RA, Sudlow C.
Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish.
Idigo NJ, Soares DC, Abbott CM.
Treatments in Aicardi-Goutières syndrome.
Crow YJ, Shetty J, Livingston JH.
Validating the accuracy of administrative healthcare data identifying epilepsy in deceased adults: A Scottish data linkage study.
Mbizvo GK, Schnier C, Simpson CR, Duncan SE, Chin RFM.
What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons.
Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernández A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, Kumar S, Johnsen K, Johannsson M, Jeong J, LeBeau F, Lizio R, Lopes da Silva F, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Olichney J, Onofrj M, Palop JJ, Rowan M, Stocchi F, Struzik ZM, Tanila H, Teipel S, Taylor JP, Weiergräber M, Yener G, Young-Pearse T, Drinkenburg WH, Randall F.
Abnormal sleep in patients with epileptic or dissociative (non-epileptic) seizures: a polysomnography study.
Popkirov S, Stone J, Derry CP.
Acquired neuromyotonia in children with CASPR2 and LGI1 antibodies.
Surana S, Kumar R, Pitt M, Hafner P, Mclellan A, Davidson J, Prabakhar P, Vincent A, Hacohen Y, Wright S.
Altered dendritic spine function and integration in a mouse model of fragile X syndrome.
Booker SA, Domanski APF, Dando OR, Jackson AD, Isaac JTR, Hardingham GE, Wyllie DJA, Kind PC.
Autism in Fragile X Syndrome; A Functional MRI Study of Facial Emotion-Processing.
McKechanie AG, Campbell S, Eley SEA, Stanfield AC.
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.
Domanski APF, Booker SA, Wyllie DJA, Isaac JTR, Kind PC.
Characteristics of 698 patients with dissociative seizures: A UK multicenter study.
Goldstein LH, Robinson EJ, Reuber M, Chalder T, Callaghan H, Eastwood C, Landau S, McCrone P, Medford N, Mellers JDC, Moore M, Mosweu I, Murray J, Perdue I, Pilecka I, Richardson MP, Carson A, Stone J; CODES Study Group.
Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice.
Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, Miyakawa T.
Computational geometry analysis of dendritic spines by structured illumination microscopy.
Kashiwagi Y, Higashi T, Obashi K, Sato Y, Komiyama NH, Grant SGN, Okabe S.
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA.
Decreased functional brain response to emotional arousal and increased psychiatric symptomology in FMR1 premutation carriers.
Brown SSG, Whalley HC, Kind PC, Stanfield AC.
Differential Dependence of GABAergic and Glutamatergic Neurons on Glia for the Establishment of Synaptic Transmission.
Turko P, Groberman K, Browa F, Cobb S, Vida I.
Differential Effects of Simulated Cortical Network Lesions on Synchrony and EEG Complexity.
Ibáñez-Molina AJ, Iglesias-Parro S, Escudero J.
Epilepsia partialis continua complicated by disseminated tuberculosis and hemophagocytic lymphohistiocytosis: a case report.
Mbizvo GK, Lentell IC, Leen C, Roddie H, Derry CP, Duncan SE, Rannikmäe K.
Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews.
Mbizvo GK, Bennett K, Simpson CR, Duncan SE, Chin RFM.
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, Story DJ, Blackwood DHR, Wyllie DJA, McIntosh AM, Millar JK, Ffrench-Constant C, Hardingham GE, Lawrie SM, Chandran S.
Fragile X-associated conditions: implications for the whole family.
McKechanie AG, Barnicoat A, Trender-Gerhard I, Allison M, Stanfield AC.
Frightening and Traumatic Memories Early after Intensive Care Discharge.
Train S, Kydonaki K, Rattray J, Stephen J, Weir CJ, Walsh TS.
Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy.
Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA.
Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy.
Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA.
GRIN2A-related disorders: genotype and functional consequence predict phenotype.
Strehlow V, Heyne HO, Vlaskamp DRM, Marwick KFM, Rudolf G, de Bellescize J, Biskup S, Brilstra EH, Brouwer OF, Callenbach PMC, Hentschel J, Hirsch E, Kind PC, Mignot C, Platzer K, Rump P, Skehel PA, Wyllie DJA, Hardingham GE, van Ravenswaaij-Arts CMA, Lesca G, Lemke JR; GRIN2A study group.
Hiding in Plain Sight: Functional Neurological Disorders in the News.
Popkirov S, Nicholson TR, Bloem BR, Cock HR, Derry CP, Duncan R, Dworetzky BA, Edwards MJ, Espay AJ, Hallett M, Lang AE, Leach JP, Lehn A, McGonigal A, Morgante F, Perez DL, Reuber M, Richardson MP, Smith P, Stamelou M, Tijssen MAJ, Tinazzi M, Carson AJ, Stone J.
How to design a dose-finding study using the continual reassessment method.
Wheeler GM, Mander AP, Bedding A, Brock K, Cornelius V, Grieve AP, Jaki T, Love SB, Odondi L, Weir CJ, Yap C, Bond SJ.
Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data.
Wilkinson T, Schnier C, Bush K, Rannikmäe K, Henshall DE, Lerpiniere C, Allen NE, Flaig R, Russ TC, Bathgate D, Pal S, O'Brien JT, Sudlow CLM; Dementias Platform UK and UK Biobank.
In Vitro Generation and Electrophysiological Characterization of OPCs and Oligodendrocytes from Human Pluripotent Stem Cells.
Magnani D, Chandran S, Wyllie DJA, Livesey MR.
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort.
Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M.
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.
Booker SA, Simões de Oliveira L, Anstey NJ, Kozic Z, Dando OR, Jackson AD, Baxter PS, Isom LL, Sherman DL, Hardingham GE, Brophy PJ, Wyllie DJA, Kind PC.
Intelligence and memory outcomes within 10 years of childhood convulsive status epilepticus.
Martinos MM, Pujar S, O'Reilly H, de Haan M, Neville BGR, Scott RC, Chin RFM.
Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model.
Muscas M, Louros SR, Osterweil EK.
Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.
Munro DAD, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, Dzierzak E, Kalisky T, Hohenstein P, Davies JA.
Neurobehavioral problems in children with early-onset epilepsy: A population-based study.
Hunter MB, Yoong M, Sumpter RE, Verity K, Shetty J, McLellan A, Jones J, Quigley A, Tallur KK, Chin RFM.
Pathogenicity and selective constraint on variation near splice sites.
Lord J, Gallone G, Short PJ, McRae JF, Ironfield H, Wynn EH, Gerety SS, He L, Kerr B, Johnson DS, McCann E, Kinning E, Flinter F, Temple IK, Clayton-Smith J, McEntagart M, Lynch SA, Joss S, Douzgou S, Dabir T, Clowes V, McConnell VPM, Lam W, Wright CF, FitzPatrick DR, Firth HV, Barrett JC, Hurles ME;
Deciphering Developmental Disorders study.
Predictors of psychotic symptoms among young people with special educational needs.
Stanfield AC, McKechanie AG, Lawrie SM, Johnstone EC, Owens DGC.
Reporting rare paediatric progressive genetic conditions: a step towards international classification.
Chin RF.
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.
Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, Hardingham GE, Wyllie DJA, Johnstone EC, Whalley HC, McIntosh AM, Lawrie SM, Chandran S.
Seizure frequency, healthcare resource utilisation and mortality in childhood epilepsy: a retrospective cohort study using the THIN database.
Myland M, Buysse B, Tsong W, Power GS, Nordli D, Chin RFM.
Severity Assessment in CDKL5 Deficiency Disorder.
Demarest S, Pestana-Knight EM, Olson HE, Downs J, Marsh ED, Kaufmann WE, Partridge CA, Leonard H, Gwadry-Sridhar F, Frame KE, Cross JH, Chin RFM, Parikh S, Panzer A, Weisenberg J, Utley K, Jaksha A, Amin S, Khwaja O, Devinsky O, Neul JL, Percy AK, Benke TA.
SuperCLEM: an accessible correlative light and electron microscopy approach for investigation of neurons and glia in vitro.
Booth DG, Beckett AJ, Prior IA, Meijer D.
Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.
Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC.
Synaptic vesicle generation from activity-dependent bulk endosomes requires a dephosphorylation-dependent dynamin-syndapin interaction.
Cheung G, Cousin MA.
Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels.
Kokotos AC, Harper CB, Marland JRK, Smillie KJ, Cousin MA, Gordon SL.
Tensor decomposition of TMS-induced EEG oscillations reveals data-driven profiles of antiepileptic drug effects.
Tangwiriyasakul C, Premoli I, Spyrou L, Chin RF, Escudero J, Richardson MP.
The CHD8 overgrowth syndrome: A detailed evaluation of an emerging overgrowth phenotype in 27 patients.
Ostrowski PJ, Zachariou A, Loveday C, Beleza-Meireles A, Bertoli M, Dean J, Douglas AGL, Ellis I, Foster A, Graham JM, Hague J, Hilhorst-Hofstee Y, Hoffer M, Johnson D, Josifova D, Kant SG, Kini U, Lachlan K, Lam W, Lees M, Lynch S, Maitz S, McKee S, Metcalfe K, Nathanson K, Ockeloen CW, Parker MJ, Pierson TM, Rahikkala E, Sanchez-Lara PA, Spano A, Van Maldergem L, Cole T, Douzgou S, Tatton-Brown K.
The evaluation and costs of transition programs for youth with epilepsy.
Nabbout R, Arzimanoglou A, Chin RFM, Grinspan Z, Speechley K, Camfield P.
The human NMDA receptor GluN2AN615K variant influences channel blocker potency.
Marwick KFM, Skehel PA, Hardingham GE, Wyllie DJA.
The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages.
Hume DA, Irvine KM, Pridans C.
The outcomes of childhood convulsive status epilepticus.
Chin RFM.
The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders.
McLachlan F, Sires AM, Abbott CM.
The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms.
Chanaday NL, Cousin MA, Milosevic I, Watanabe S, Morgan JR.
A practical guide to pre-trial simulations for Bayesian adaptive trials using SAS and BUGS.
Hansen CH, Warner P, Walker A, Parker RA, Whitaker L, Critchley HOD, Weir CJ.
Accuracy and utility of using administrative healthcare databases to identify people with epilepsy: a protocol for a systematic review and meta-analysis.
Mbizvo GK, Bennett K, Simpson CR, Duncan SE, Chin RFM.
Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11.
Kokotos AC, Peltier J, Davenport EC, Trost M, Cousin MA.
Adaptive designs in clinical trials: why use them, and how to run and report them.
Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR, Villar SS, Wason JMS, Weir CJ, Wheeler GM, Yap C, Jaki T.
Adaptive Windowing Framework for Surface Electromyogram-Based Pattern Recognition System for Transradial Amputees.
Al-Timemy AH, Bugmann G, Escudero J.
AEDs or no AEDs during pregnancy? That is the question.
Chin RFM.
Amplitude- and Fluctuation-Based Dispersion Entropy.
Azami H, Escudero J.
Architecture of the Mouse Brain Synaptome.
Zhu F, Cizeron M, Qiu Z, Benavides-Piccione R, Kopanitsa MV, Skene NG, Koniaris B, DeFelipe J, Fransén E, Komiyama NH, Grant SGN.
Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors.
O'Neill N, McLaughlin C, Komiyama N, Sylantyev S.
Brain-related comorbidities in boys and men with Duchenne Muscular Dystrophy: A descriptive study.
Hendriksen RGF, Vles JSH, Aalbers MW, Chin RFM, Hendriksen JGM.
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.
Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S.
Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/- mice.
Kopanitsa MV, Gou G, Afinowi NO, Bayés À, Grant SGN, Komiyama NH.
Clinical features, course, and outcomes of a UK cohort of pediatric moyamoya.
Tho-Calvi SC, Thompson D, Saunders D, Agrawal S, Basu A, Chitre M, Chow G, Gibbon F, Hart A, Tallur KK, Kirkham F, Kneen R, McCullagh H, Mewasingh L, Vassallo G, Vijayakumar K, Wraige E, Yeo TH, Ganesan V; British Paediatric Neurology Association Moyamoya Study group.
Coarse-Graining Approaches in Univariate Multiscale Sample and Dispersion Entropy.
Azami H, Escudero J.
Cognitive impairment in early onset epilepsy is associated with reduced left thalamic volume.
Yoong M, Hunter M, Stephen J, Quigley A, Jones J, Shetty J, McLellan A, Bastin ME, Chin RFM.
Complexity analysis of spontaneous brain activity in mood disorders: A magnetoencephalography study of bipolar disorder and major depression.
Fernández A, Al-Timemy AH, Ferre F, Rubio G, Escudero J.
Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review.
Weir CJ, Butcher I, Assi V, Lewis SC, Murray GD, Langhorne P, Brady MC.
Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.
Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F, Walton MK, Biggs K, Nicholl J, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG.
Discrimination of stroke-related mild cognitive impairment and vascular dementia using EEG signal analysis.
Al-Qazzaz NK, Ali SHBM, Ahmad SA, Islam MS, Escudero J.
Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.
Coba MP, Ramaker MJ, Ho EV, Thompson SL, Komiyama NH, Grant SGN, Knowles JA, Dulawa SC.
Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95.
Horner AE, McLaughlin CL, Afinowi NO, Bussey TJ, Saksida LM, Komiyama NH, Grant SGN, Kopanitsa MV.
Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder.
Tillmann J, Ashwood K, Absoud M, Bölte S, Bonnet-Brilhault F, Buitelaar JK, Calderoni S, Calvo R, Canal-Bedia R, Canitano R, De Bildt A, Gomot M, Hoekstra PJ, Kaale A, McConachie H, Murphy DG, Narzisi A, Oosterling I, Pejovic-Milovancevic M, Persico AM, Puig O, Roeyers H, Rommelse N, Sacco R, Scandurra V, Stanfield AC, Zander E, Charman T.
Evaluation of matrix factorisation approaches for muscle synergy extraction.
Ebied A, Kinney-Lang E, Spyrou L, Escudero J.
Experiential contributions to social dominance in a rat model of fragile-X syndrome.
Saxena K, Webster J, Hallas-Potts A, Mackenzie R, Spooner PA, Thomson D, Kind P, Chattarji S, Morris RGM.
Identifying dementia cases with routinely collected health data: A systematic review.
Wilkinson T, Ly A, Schnier C, Rannikmäe K, Bush K, Brayne C, Quinn TJ, Sudlow CLM; UK Biobank Neurodegenerative Outcomes Group and Dementias Platform UK.
Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex Spike Timing.
Garden DLF, Oostland M, Jelitai M, Rinaldi A, Duguid I, Nolan MF.
International variation in programmes for assessment of children's neurodevelopment in the community: Understanding disparate approaches to evaluation of motor, social, emotional, behavioural and cognitive function.
Wilson P, Wood R, Lykke K, Hauskov Graungaard A, Ertmann RK, Andersen MK, Haavet OR, Lagerløv P, Abildsnes E, Dahli MP, Mäkelä M, Varinen A, Hietanen M.
'It just opens up their world': autism, empathy, and the therapeutic effects of equine interactions.
Malcolm R, Ecks S, Pickersgill M.
Long-term behavioural outcomes after paediatric convulsive status epilepticus: a population-based cohort study.
Martinos MM, Pujar S, Gillberg C, Cortina-Borja M, Neville BGR, De Haan M, Scott RC, Chin RFM.
Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study.
Pujar SS, Martinos MM, Cortina-Borja M, Chong WKK, De Haan M, Gillberg C, Neville BG, Scott RC, Chin RF; North London Epilepsy Research Network.
Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.
Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel PA, Wyllie DJA, Jackson M.
Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study.
Jammeh EA, Carroll CB, Pearson SW, Escudero J, Anastasiou A, Zhao P, Chenore T, Zajicek J, Ifeachor E.
Mavoglurant in Fragile X Syndrome: Results of two open-label, extension trials in adults and adolescents.
Hagerman R, Jacquemont S, Berry-Kravis E, Des Portes V, Stanfield A, Koumaras B, Rosenkranz G, Murgia A, Wolf C, Apostol G, von Raison F.
Medical Mechatronics for Healthcare.
Liu YH, Moratal D, Escudero J, Huang HP.
Memory complaints in epilepsy: An examination of the role of mood and illness perceptions.
Tinson D, Crockford C, Gharooni S, Russell H, Zoeller S, Leavy Y, Lloyd R, Duncan S.
Modelling the details: integrating structure with function.
Wyllie DJA.
Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons.
Booker SA, Loreth D, Gee AL, Watanabe M, Kind PC, Wyllie DJA, Kulik Á, Vida I.
Short-term Seizure Outcomes in Childhood Epilepsy.
Aaberg KM, Bakken IJ, Lossius MI, Lund Søraas C, Tallur KK, Stoltenberg C, Chin R, Surén P.
Sinus pericranii: long-term outcome in a 10-year-old boy with a review of literature.
Goffin J, MacKenzie SA, Tallur KK, Kaliaperumal C.
Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning.
Tennant SA, Fischer L, Garden DLF, Gerlei KZ, Martinez-Gonzalez C, McClure C, Wood ER, Nolan MF.
Study of the Mozart effect in children with epileptic electroencephalograms.
Grylls E, Kinsky M, Baggott A, Wabnitz C, McLellan A.
SYT1-associated neurodevelopmental disorder: a case series.
Baker K, Gordon SL, Melland H, Bumbak F, Scott DJ, Jiang TJ, Owen D, Turner BJ, Boyd SG, Rossi M, Al-Raqad M, Elpeleg O, Peck D, Mancini GMS, Wilke M, Zollino M, Marangi G, Weigand H, Borggraefe I, Haack T, Stark Z, Sadedin S; Broad Center for Mendelian Genomics, Tan TY, Jiang Y, Gibbs RA, Ellingwood S, Amaral M, Kelley W, Kurian MA, Cousin MA, Raymond FL.
Tensor-driven extraction of developmental features from varying paediatric EEG datasets.
Kinney-Lang E, Spyrou L, Ebied A, Chin RFM, Escudero J.
The acute medical unit model: A characterisation based upon the National Health Service in Scotland.
Reid LEM, Pretsch U, Jones MC, Lone NI, Weir CJ, Morrison Z.
The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer.
Jaarsma D, Blot FGC, Wu B, Venkatesan S, Voogd J, Meijer D, Ruigrok TJH, Gao Z, Schonewille M, De Zeeuw CI.
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
McKay S, Ryan TJ, McQueen J, Indersmitten T, Marwick KFM, Hasel P, Kopanitsa MV, Baxter PS, Martel MA, Kind PC, Wyllie DJA, O'Dell TJ, Grant SGN, Hardingham GE, Komiyama NH.
The diagnosis, burden and prognosis of dementia: A record-linkage cohort study in England.
Pujades-Rodriguez M, Assi V, Gonzalez-Izquierdo A, Wilkinson T, Schnier C, Sudlow C, Hemingway H, Whiteley WN.
Trends in epilepsy admissions in children, 1981-2013: population-based observational study using the Scottish national hospital discharge database.
Chin RFM, Stephen J, Weir CJ, Wood R.
Using FM Dyes to Monitor Clathrin-Mediated Endocytosis in Primary Neuronal Culture.
Cousin MA, Gordon SL, Smillie KJ.
Brain-related comorbidities in boys and men with Duchenne Muscular Dystrophy: A descriptive study.
Authors
Hendriksen RGF, Vies JSH, Aalbers MW, Chin RFM, Hendriksen JGM. Eur J Paediatr Neurol. 2017 Dec.
Description
In a Dutch-Scottish collaboration study with questionnaires directed to an international population, this study suggests that almost one in thirteen children with Duchenne have epilepsy and that other brain-related comorbidities were higher if both conditions co-existed. However, the study may have been biased because there was not a universal response so future studies are needed to determine true incidence.
Long-term behavioural outcomes after paediatric convulsive status epilepticus: a population-based cohort study.
Authors
Martinos MM, Pujar S, Gillberg C, Cortina-Borja M, Neville BGR, De Haan M, Scott RC, Chin RFM. Dev Med Child Neurol. 2017 Dec.
Description
Having established the first study focused on prolonged seizures in children, Chin and colleagues followed this unique cohort for 8 years after their initial episode of prolonged seizures to determine behavioural outcomes. Just over a quarter had a behavioural/psychiatric disorder (including ADHD and autism spectrum disorders) with those who had epilepsy at the time of the prolonged seizures being more severely affected. Repeated episodes of prolonged seizures or having had previous seizures before the initial episode increases the risk for subsequent problems.
Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group.
Authors
Leach JP, Smith PE, Craig J, Bagary M, Cavanagh D, Duncan S, Kelso ARC, Marson AG, McCorry D, Nashef L, Nelson-Piercy C, Northridge R, Sieradzan K, Thangaratinam S, Walker M, Winterbottom J, Reuber M. Seizure. 2017 Aug; 50:67-72.
Description
This paper summarises findings of a multidisciplinary meeting with representation from a wide group of professional bodies aimed at producing the best epilepsy pregnancy care to reduce mortality in expectant mothers with epilepsy, and reduce problems in their children. The authors identified Golden Moments of opportunities for improving outcomes, Key Groups to making change, and aimed to have these improvements in place by 2020.
Monitoring activity-dependent bulk endocytosis with the genetically-encoded reporter VAMP4-pHluorin.
Authors
Nicholson-Fish JC, Smillie KJ, Cousin MA. J Neurosci Methods. 2016 Jun; 266: 1-10.
Description
Having previously shown that abnormalities in activity-dependent bulk endocytosis may be implicated as a cause for epilepsy, and a potential target for development of novel antiepileptic drugs, the authors provide a new method to monitor the endocytosis mode.
Accounting for the complex hierarchical topology of EEG phase-based functional connectivity in network binarisation.
Authors
Smith K, Absalo D, Escudero J. PLoS One. 2017 Oct; 12(10).
Description
There is evidence of interconnectivity of different parts of the brain, with varying degrees of network connectivity. How to measure these networks using imaging and EEG techniques, and how networks are involved in normal learning and behaviour as well as in diseases of the brain are a major research focus in laboratories worldwide. In this paper, the authors provide new evidence of the importance of considering a large number of edges in EEG connectivity network research.
Discrimination of stroke-related mild cognitive impairment and vascular dementia using EEG signal analysis.
Authors
Al-Qazzaz NK, Ali SHBM, Ahmad SA, Islam MS, Escudero J. Med Biol Eng Comput. 2017 Nov.
Description
EEGs are often used primarily for diagnosis and monitoring treatment of seizures. However, there is increasing use of EEG in identifying problems in learning and behaviour. Dr Escudero and colleagues demonstrate novel analytical methods of EEGs that may help in distinguishing between patients with stroke related cognitive problems and those with vascular dementia.
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women.
Authors
Bethlehem RAI, Lombardo MV, Lai MC, Auyeung B, Crockford SK, Deakin J, Soubramanian S, Sule A, Kundu P, Voon V, Baron-Cohen S. Transl Psychiatry. 2017 Apr; 7(4).
Description
The cause for gender differences in the incidence of different types of epilepsy and associated comorbidity is often unclear. This paper demonstrates that the naturally occurring hormone oxytocin affects brain connectivity in women. This may contribute to the differences in subsets of people with neurological conditions, including epilepsy.
Flexible theta sequence compression mediated via phase precessing interneurons.
Authors
Chadwick A, Van Rossum MC, Nolan MF. Elife. 2016 Dec; 5.
Description
Abnormalities in the function of specific brain cells, interneurons, are a possible cause for seizures in people with epilepsy. Learning problems are common in people with epilepsy, independent of seizure control, but the mechanism for these problems are unclear. In this study, Matt Nolan and colleagues demonstrate a mechanism of encoding information through interneuron-dependent brain rhythms.
Providing experiential information on early medical abortion: a qualitative evaluation of an animated personal account, Lara's Story.
Authors
Sherman S, Harden J, Cattanach D, Cameron ST. J Fam Plann Reprod Health Care. 2017 Oct; 43(4).
Description
Data on a doctoral project being supervised by MMEC’s Jeni Harden, one of the authors of this paper, show children with epilepsy often have limited knowledge about epilepsy. Publicly readily available information about epilepsy, aside from written information, specifically designed with children with mind are sparse. The current study shows that an animated film on early medical abortion might be valuable in providing information for women considering this procedure. Extrapolating from this, an animation film about epilepsy could be helpful in providing children with much needed information about the disease.
Linking routinely collected social work, education and health data to enable monitoring of the health and health care of school-aged children in state care ('looked after children') in Scotland: a national demonstration project.
Authors
Clark D, King A, Sharpe K, Connelly G, Elliott L, Macpherson LMD, McMahon AD, Milligan I, Wilson P, Conway DI, Wood R. Public Health. 2017 Sep; 150.
Description
Dr Wood and colleagues demonstrate the strong potential of linking Scotland’s routine administrative social, education and health data to investigate the health outcomes of school aged children. By extending their method they propose to be able to include information on children who are not in public funded schooling.
Seizures, syndromes, and etiologies in childhood epilepsy: The International League Against Epilepsy 1981, 1989, and 2017 classifications used in a population-based cohort.
Authors
Aaberg KM, Surén P, Søraas CL, Bakken IJ, Lossius MI, Stoltenberg C, Chin R. Epilepsia. 2017 Sep.
Description
In one of the first published studies to use the new ILAE classification scheme for epilepsy, and apply it to the largest validated and phenotyped epilepsy cohorts identified from a birth cohort worldwide, the Norway-UK researchers show: (1) the new classification allows for a greater precision in diagnoses which may help with prognosis, treatment and trying to find causes but as this requires detailed investigative results, may result in more epilepsies being unclassifiable pending results/availability of tests. (2) Despite advances in technology, the cause of epilepsy still remains unknown in most children.
RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.
Authors
Reijnders MRF, Ansor NM, Kousi M, Yue WW, Tan PL, Clarkson K, Clayton-Smith J, Corning K, Jones JR, Lam WWK, Mancini GMS, Marcelis C, Mohammed S, Pfundt R, Roifman M, Cohn R, Chitayat D; Deciphering Developmental Disorders Study, Millard TH, Katsanis N, Brunner HG, Banka S. Am J Hum Genet. 2017 Sep; 101(3).
Description
Dr Lam and colleagues through an international collaborative study reveals the role of mutations in RAC1 gene in neurodevelopmental disorders
Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder.
Authors
Harper CB, Mancini GMS, van Slegtenhorst M, Cousin MA. Neurobiol Dis. 2017 Sep; 108.
Description
MMEC Pre-clinical lead Mike Cousin and his team reveal a form of severe intellectual disability and epilepsy found in a single patient was caused by a mutation in the SYP gene. They went on to show that this mutation specifically affected movement of a key protein for neuron communication – synaptobrevin II. They showed that this defect was also seen with other human mutations in SYP, this time from X-linked intellectual disability. Therefore correcting the altered movement of synaptobrevin II may be a potential avenue for therapeutic intervention in both epilepsy and intellectual disability.
Investigating Sex Bias in the AQ-10: A Replication Study.
Authors
Murray AL, Booth T, Auyeung B, McKenzie K, Kuenssberg R. Assessment. 2017 Sep; 1073191117733548.
Description
Autism is a common comorbidity in epilepsy and those on the milder end of the spectrum can be difficult to identify. Thus, screening methods for autism are important. This study confirms that a novel screening instrument (AQ-10) which determines who would benefit from more detailed testing, is not biased against females. Nonetheless the authors suggest one item to be replaced.
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
Authors
Thomson SR, Seo SS, Barnes SA, Louros SR, Muscas M, Dando O, Kirby C, Wyllie DJA, Hardingham GE, Kind PC, Osterweil EK. Neuron. 2017 Aug; 95(3).
Description
Fragile X syndrome (FXS) is the most common form of inherited X-linked intellectual disability, with patients often displaying epilepsy. FXS is thought to be caused by excessive synthesis of specific types of proteins controlled by FMRP, which is mutated in FXS. . The Osterweil group showed common FXS symptoms (including seizures) can be reversed in a model system by activating a pathway dependent on the neurotransmitter acetylcholine. Interestingly proteins for this pathway are increased in FXS, showing that enhancement of specific proteins may be beneficial preventing FXS symptoms, including seizures.
Familial epilepsy with anterior polymicrogyria as a presentation of COL18A1 mutations.
Authors
Corbett MA, Turner SJ, Gardner A, Silver J, Stankovich J, Leventer RJ, Derry CP, Carroll R, Ha T, Scheffer IE, Bahlo M, Jackson GD, Mackey DA, Berkovic SF, Gecz J. Eur J Med Genet. 2017 Aug; 60(8).
Description
Chris Derry from MMEC and colleagues discover mutations in COL18A1 gene in four sisters. These sisters display Lennox-Gastaut type severe refractory epilepsy and abnormality in the formation of the front of the brain. This finding is novel since it identifies a genetic, inherited cause for Lennox Gastatut Syndrome. Previously this genetic mutation was usually found in another neurological disorder therefore this study expands the types of diseases/conditions that occur due to abnormalities in COL18A1.
Estimating numbers of children with cerebral palsy: a call to action.
Authors
Wood R. Dev Med Child Neurol. 2017 Aug; 59(8).
Description
Dr. Wood comments on an original article by Glinianaia et al. on “Predicting the prevalence of cerebral palsy by severity level in children aged 3 to 15 years across England and Wales by 2020” Dr. Wood emphasises that the key message arising from the paper by Glinianaia et al. is that, austerity and service cuts notwithstanding, the need for robust, integrated services for children (and their families) with complex needs is unlikely to diminish in the short to medium term. Regardless of advances in prevention, there will always be children with significant impairment and disability, and how we collectively organize and deliver services to meet their needs will remain a measure of our society.
Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group.
Authors
Leach JP, Smith PE, Craig J, Bagary M, Cavanagh D, Duncan S, Kelso ARC, Marson AG, McCorry D, Nashef L, Nelson-Piercy C, Northridge R, Sieradzan K, Thangaratinam S, Walker M, Winterbottom J, Reuber M. Seizure. 2017 Aug; 50.
Description
Susan Duncan, head of the adult epilepsy service in Edinburgh, and other members of the UK wide epilepsy mortality group put forward suggestions to optimise pregnancy care in women with epilepsy. The aim is to reduce maternal mortality and morbidity in children exposed to anti-epileptic medication whilst they are in the womb.
Can the Apgar Score be Used for International Comparisons of Newborn Health?
Authors
Siddiqui A, Cuttini M, Wood R, Velebil P, Delnord M, Zile I, Barros H, Gissler M, Hindori-Mohangoo AD, Blondel B, Zeitlin J; Euro-Peristat Scientific Committee. Paediatr Perinat Epidemiol. 2017 Jul; 31(4).
Description
The APGAR Score, usually given at 1 minute, 5 minutes, and 10 minutes after birth is often used to predict mortality within the first month of life. Furthermore lower scores are associated with long term health problems in children who survive past the first month of life. Dr. Wood and colleagues show that there is a large variation in APGAR scoring amongst countries, likely due to national scoring practices, makes the APGAR score an unsuitable indicator for comparing health in the newborn across countries.
Incidence and Prevalence of Childhood Epilepsy: A Nationwide Cohort Study.
Authors
Aaberg KM, Gunnes N, Bakken IJ, Lund Søraas C, Berntsen A, Magnus P, Lossius MI, Stoltenberg C, Chin R, Surén P. Pediatrics. 2017 May;139(5).
Description
In the second of a series of papers from a collaboration between the Norwegian Institute of Public Health and the University of Edinburgh, the researchers provide up to date information on the incidence of childhood epilepsy. The importance, strength and merits of analysing data collected routinely in clinical practice, often referred to as “Big Data” is increasingly being recognised. This paper demonstrates the importance of the validation of epilepsy diagnoses in such data, since a third of children can be erroneously coded as having epilepsy when they do not. The now validated epilepsy cohort is part of a much larger birth cohort and will allow the researchers to examine the development of children with epilepsy compared to those without, the prenatal and postnatal factors that lead to an increased risk for epilepsy and related neurodevelopmental problems, and factors that improve outcomes.
Long-term white matter tract reorganization following prolonged febrile seizures.
Authors
Pujar SS, Seunarine KK, Martinos MM, Neville BG, Scott RC, Chin RF, Clark CA. Epilepsia. 2017 May;58(5):772-780.
Description
Febrile seizures occur in 3 per 100 children between the ages of 6 months to 5 years. They generally last less than 5 minutes but can go on for longer than 30 minutes. These longer seizures, prolonged febrile seizures, are thought to cause brain damage. In this study of a unique group of children with prolonged febrile seizures, researchers from UCL and the University of Edinburgh report findings that suggest prolonged febrile seizures can interfere with usual development of how different parts of the brain connect with each other but adopts to this within 8 years through changes in the microstructure and organisation of the connective tracts of the brain.
Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice.
Authors
Davies FC, Hope JE, McLachlan F, Nunez F, Doig J, Bengani H, Smith C, Abbott CM.
Description
Mutations in the gene EF1A2 have recently been found to give rise to neurodevelopmental disorders. In pre-clinical studies, the researchers produced mice with the mutation G70S (the most frequently occurring mutation in humans) in the eEF1A2 gene some of which have seizures and sudden death. They conclude that the abnormal protein formed due to this gene mutation is essentially non-functional, suggesting this disorder results from loss of normal eEF1A2 function
Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy.
Authors
Currie SP, Luz LL, Booker SA, Wyllie DJ, Kind PC, Daw MI. Epilepsia. 2017 Apr;58(4):597-607.
Description
Developmental concerns and or problems can exist prior to the onset of seizures. Why cognitive and behavioural problems occur in a high proportion of people with epilepsy is unclear. This study shows that in an experimental model of a specific type of epilepsy, childhood absence epilepsy, there are changes in the way that the brain is usually connected PRIOR to the onset of seizures.
A (free) radical approach reveals the physiological function of different synaptic vesicle pools.
Authors
Cousin MA. J Physiol. 2017 Feb 15;595(4):1005-1006.
Description
Synaptic vesicles (SVs) store neurotransmitter inside brain cells and during neuronal activity are triggered to release their contents to evoke neuronal communication. This short commentary article highlighted our growing understanding that not all SVs are created equal, and that there are different populations that mediate different types of neurotransmission. This may be important for neurotransmitter release during epilepsy, and identifying which SVs are responsible may allow excessive neurotransmission to be limited.
Alterations in the properties of neonatal thalamocortical synapses with time in in vitro slices.
Authors
Luz LL, Currie SP, Daw MI. PLoS One. 2017 Feb 8;12(2):e0171897.
Description
Preclinical, non-human studies are important to increase understanding of and development of treatments for epilepsy. Brain cells are constantly being formed and lost in the living brain with those that remain forming connections between them. This study shows the way that brain cells communicate with each other in experimental studies of brain slices in specialised preparations changes over time. Thus, in experiments using this technique, this has to be borne in mind.
The complex hierarchical topology of EEG functional connectivity.
Authors
Smith K, Escudero J. J Neurosci Methods. 2017 Jan 30;276:1-12.
Description
EEGs have traditionally been used to help in the diagnosis and treatment of epilepsy. There is increasing interest in using EEG to develop networks to enhance our understanding of how the brain is connected and how it works. This paper provides insight into the complex ways that brain networks are organised.
Grid cells' need for speed.
Authors
Gonzalez-Sulser A, Nolan MF. Nat Neurosci. 2016 Dec 27;20(1):1-2.
Description
Grid-firing fields of neurons in the entorhinal cortex are thought to require inputs encoding running speed. Glutamatergic projections from the medial septum may be one of the inputs that provide these speed signals.
5-Hydroxyvitamin D concentration in paediatric cancer patients from Scotland: a prospective cohort study.
Authors
Iniesta RR, Paciarotti I, Davidson I, McKenzie JM, Brand C, Chin RF, Brougham MF, Wilson DC. Br J Nutr. 2016 Dec;116(11):1926-1934.
Description
This study showed that in Scotland, children with cancer are at no higher risk of having low Vitamin D levels compared to children in the general Scottish population. However, in both groups, low levels are common. Older children with cancer, or those who are overweight or not taking vitamin D supplements are more likely to have low levels. The study collaborators in oncology, gastroenterology and neurology services at the Royal Hospital for Sick Children in Edinburgh recommended that supplementation and monitoring should implemented. Vitamin D levels in the “healthy” control group of children were obtained through a parallel study funded by the Roald Dahl Marvellous Children’s Charity, examining Vitamin D levels in Scottish children with epilepsy versus those without.
Flexible theta sequence compression mediated via phase precessing interneurons.
Authors
Chadwick A, van Rossum MC, Nolan MF. Elife. 2016 Dec 8;5.
Description
The brain electrical activity varies throughout the day and even at the same time period, there can be marked variation of electrical activity within different parts of the brain. These electrical activities have a rhythm and are described as oscillations. Maintenance of these oscillations are linked to learning and if they become abnormal could be associated with development of seizures. In this paper, the authors report on how the medial septum of the brain (a potential target for novel epilepsy treatments) influences oscillations.
Quantifying and exploring camouflaging in men and women with autism.
Authors
Lai MC, Lombardo MV, Ruigrok AN, Chakrabarti B, Auyeung B, Szatmari P, Happé F, Baron-Cohen S; MRC AIMS Consortium. Autism. 2016 Nov 29.
Description
The co-occurrence of epilepsy and autism is common. From a study carried out by a consortium of researchers, Dr. Auyeung and colleagues investigated if and how people with autism “camouflage” their social communication difficulties. They found that the degree of camouflaging was not significantly influenced by age or IQ. On average, women with autism had higher camouflaging scores than men with autism with substantial variability in both groups. Greater camouflaging was associated with more depressive symptoms in men.
Investigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ-10.
Authors
Murray AL, Allison C, Smith PL, Baron-Cohen S, Booth T, Auyeung B. Autism Res. 2016 Nov 28.
Description
There are more than 40 different types of epilepsy, and there are many autism spectrum conditions (ASC). This study addresses the possibility of misdiagnosis or underdiagnosis using the AQ-10, a screening test for ASC recommended by the National Institute of Clinical Excellence. Dr. Auyeung and colleagues show that some items were biased towards males and others to females but overall there was no bias. This supports the continued use of AQ-10 as a screening test, but caution should be exercised when interpreting responses to individual items.
Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders.
Authors
Ruth R. Shah, Justyna Cholewa-Waclaw, Faith C.J. Davies, Katie M. Paton, Ronan Chaligne, Edith Heard, Catherine M. Abbott, Adrian P. Bird. Wellcome Open Res. 2016 Nov 15; 1: 13.
Description
There is increasing evidence of the role of genetic abnormalities in diseases of the nervous system, including epilepsy. Identification of a genetic abnormality is insufficient on its own and more work is needed to understand the changes in function that result from this event and thus the changes in biology in humans. Understanding this can be highly beneficial with prognostication and development of therapies. In this paper, Prof Abbott and colleagues show how a novel technique CRISPR/Cas 9 can be used to introduce genetic abnormalities in human brain cells. This is usually a very difficult process for brain cells that are grown in dishes. This new work opens up potential to study the mechanism of human brain diseases including Rett Syndrome and EEF1A2 disorder.
Continuous attractor network models of grid cell firing based on excitatory-inhibitory interactions.
Authors
Shipston-Sharman O, Solanka L, Nolan MF. J Physiol. 2016 Nov 15;594(22):6547-6557.
Description
Seizures arise because of an imbalance between excitatory and inhibitory mechanisms in the brain. In this paper, the authors discuss evidence for continuous attractor network models that account for grid firing by synaptic interactions between excitatory and inhibitory cells.
Seizure variables and their relationship to genotype and functional abilities in the CDKL5 disorder.
Fehr S, Wong K, Chin R, Williams S, de Klerk N, Forbes D, Krishnaraj R, Christodoulou J, Downs J, Leonard H. Neurology. 2016 Nov;87(21):2206-2213.
Expanding the (kaleido)scope: exploring current literature trends for translating electroencephalography (EEG) based brain-computer interfaces for motor rehabilitation in children.
Kinney-Lang E, Auyeung B, Escudero J. Journal of Neural Engineering. 2016 Oct;13(6).
Comorbidity and childhood epilepsy: A nationwide registry study.
Aaberg KM, Bakken IJ, Lossius MI, Lund Soraas C, Haberg SE, Stoltenberg C, Suren P, Chin R. Pediatrics. 2016 Aug;138(3).
Refined composite multivariate generalized multiscale fuzzy entropy: A tool for complexity analysis of multichannel signals.
Azami H, Escudero J. Physica A: Statistical Mechanics and its Applications. 2016 Aug;465:261-276.
Families' experiences of living with pediatric epilepsy: A qualitative systematic review.
Harden J, Black R, Chin RF. Epilepsy Behav. 2016 Jul;60:225-237.
Local field potentials get funny.
Nolan MF. The Journal of Physiology. 2016 Jul;594(13):3487-3488.
Monitoring activity-dependent bulk endocytosis with the genetically-encoded reporter VAMP4-pHluorin.
Nicholson-Fish JC, Smillie KJ, Cousin MA. J Neurosci Methods. 2016 Jun;266:1-10.
Amplitude-aware permutation entropy: Illustration in spike detection and signal segmentation.
Authors
Azami H, Escudero J. Comput Methods Programs Biomed. 2016 May;128:40-51.
Description
The detection of spikes on EEGs is an important part of the diagnosis and treatment of epilepsy. Seizure detection devices rely on automated detection of such spikes but if there are irregularities in the trace from movement or other artefacts, this can be difficult or impossible. The authors report their discovery of a novel method of detecting spikes and announce the free availability of the code.
Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability.
Lam WWK, Millichap JJ, Soares DC, Chin R, McLellan A, FitzPatrick DR, Elmslie F, Lees MM, Schaefer GB, DDD study, Abbott CM. Molecular Genetics & Genomic Medicine. 2016 Apr;4(4):465-474.
Definition and diagnostic criteria of sleep-related hypermotor epilepsy.
Tinuper P, Bisulli F, Cross JH, Hesdorffer D, Kahane P, Nobili L, Provini F, Scheffer IE, Tassi L, Vignatelli L, Bassetti C, Cirignotta F, Derry C, Gambardella A, Guerrini R, Halasz P, Licchetta L, Mahowald M, Manni R, Marini C, Mostacci B, Naldi I, Parrino L, Picard F, Pugliatti M, Ryvlin P, Vigevano F, Zucconi M, Berkovic S, Ottman R. The Official Journal of the American Academy of Neurology. 2016 Apr;86(19):1834-1842.
Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals.
Nicholson-Fish JC, Cousin MA, Smillie KJ. Neurochem Res. 2016 Mar;41(3):534-543.
After sudden unexpected death in epilepsy: Lessons learned and the road forward.
Donner EJ, Waddell B, Osland K, Leach JP, Duncan S, Nashef L, Picot MC. Epilepsia. 2016 Jan;57(S1):46-53.
Improved multiscale permutation entropy for biomedical signal analysis: Interpretation and application to electroencephalogram recordings.
Azami H, Escudero J. Biomedical Signal Processing and Control. 2016 Jan;23:28-41.
VAMP4 is an essential cargo molecule for activity-dependent bulk endocytosis.
Nicholson-Fish JC, Kokotos AC, Gillingwater TG, Smillie KJ, Cousin MA. Neuron. 2015 Dec;88(5):973-984.
Selection of Mother Wavelet Functions for Multi-Channel EEG Signal Analysis during a Working Memory Task.
Al-Qazzaz NK, Bin Mohd Ali SH, Ahmad SA, Islam MS, Escudero J. Sensors (Basel). 2015 Nov;15(11):29015-29035.
Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice.
Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nagerl UV, Kind PC, Wyllie DJ. Journal of Neuroscience. 2015 Nov;35(45):15073-15081.
Features of developmental coordination disorder in active childhood epilepsy: a population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Dev Med Child Neurol. 2015 Sep;57(9):829-34.
Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis.
Morton A, Marland JR, Cousin MA. J Neurochem. 2015 Aug;134(3):405-15.
The health, education, and social care costs of school-aged children with active epilepsy: A population-based study.
Hunter RM, Reilly C, Atkinson P, Das KB, Gillberg C, Chin RF, Scott RC, Neville BG, Morris S. Epilepsia. 2015 Jul;56(7):1056-64.
Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks.
Solanka L, van Rossum MC, Nolan MF. eLife. 2015 Jul;4.
Prescription of emergency antiepileptic medication after a first childhood seizure: analysis of routine administrative data.
Chin RF, Ajetunmobi O, Weir CJ, Wood R. Epileptic Disord. 2015 Jun;17(2):172-6.
Factors associated with quality of life in active childhood epilepsy: A population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, and Neville BG. Eur J Paediatr Neurol. 2015 May;19(3):308-13.
Cognition in school-aged children with "active" epilepsy: A population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. J Clin Exp Neuropsychol. 2015 Apr;37(4):429-38.
Socioeconomic deprivation is an independent risk factor for behavioral problems in children with epilepsy.
Carson J, Weir A, Chin RF, McLellan A. Epilepsy Behav. 2015 Apr;45:105-9.
Quantifying the deficit – imaging neurobehavioural impairment in childhood epilepsy.
Yoong, M. Quan. Imaging in Med Surg. 2015 April 5(2): 225-237.
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.
Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, and Alessi DR. J Neurosci. 2015 Feb 11;35(6):2492-507.
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M. Nat Med. 2015 Jan;21(1):19-26.
Laminar and dorsoventral molecular organization of the medial entorhinal cortex revealed by large-scale anatomical analysis of gene expression.
Ramsden HL, Sürmeli G, McDonagh SG, Nolan MF. PLOS Computational Biology. 2015 Jan;11(1).
Features of autism spectrum disorder (ASD) in childhood epilepsy: a population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Epilepsy Behav. 2015 Jan;42:86-92.
A qualitative study of the reactions of young adults with epilepsy to SUDEP disclosure, perceptions of risks, views on the timing of disclosure and behavioural change.
Tonberg A. Harden J, McLellan A, Chin RF, Duncan S. Epilepsy Behav. 2015 Jan;42:98-106.
Screening for mental health disorders in active childhood epilepsy: Population-based data.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Epilepsy Res. 2014 Dec; 108(10):1917-26.
Parent- and Teacher-Reported Symptoms of ADHD in School-Aged Children With Active Epilepsy: A Population-Based Study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. J Atten Disord. 2014 Nov 21.
'If you're gonna die, you're gonna die': Young adults' perceptions of sudden unexpected death in epilepsy.
Harden J, Tonberg A, Chin RF, McLellan A, Duncan S. Chronic Illn. 2014 Oct 31.
Academic achievement in school-aged children with active epilepsy: A population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Epilepsia. 2014 Oct 20.
What are the best ways to deliver benzodiazepines in children/patients with prolonged convulsive seizures?
Chin RF. Epileptic Disord. 2014 Oct;16 Suppl 1:50-8.
Application of diffusion tensor imaging and tractography of the optic radiation in anterior temporal lobe resection for epilepsy: a systematic review.
Piper RJ, Yoong MM, Kandasamy J, Chin RF. Clin Neurol Neurosurg. 2014 Sep; 124:59-65.
Convulsive status epilepticus and health-related quality of life in children with epilepsy.
Ferro MA, Chin RF, Camfield CS, Wiebe S, Levin SD, Speechley KN. Neurology. 2014 Aug 19;83(8):752-7.
Estimating intracranial volume using intracranial area in healthy children and those with childhood status epilepticus.
Piper RJ, Yoong MM, Pujar S, Chin RF. Brain Behav. 2014 Aug 28.
Convulsive status epilepticus and health-related quality of life in children with epilepsy.
Ferro MA, Chin RF, Camfield CS, Wiebe S, Levin SD, Speechley KN. Neurology, 2014 Aug 19;83(8):752-7.
Hippocampal sclerosis and other forms of status epilepticus.
Yoong M, Martinos MM, Pujar S, Scott RC, Chin RF.Ann Neurol. 2014 Aug;76(2):316.
Neurobehavioral comorbidities in children with active epilepsy: a population-based study.
Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Pediatrics. 2014 Jun;133(6):e1586-93.
Sleeping in fits and starts: a practical guide to distinguishing nocturnal epilepsy from sleep disorders.
Derry CP. Pract Neurol. 2014 Jun 9. pii: practneurol-2014-000890.
Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination.
Kegel L, Jaegle M, Driegen S, Aunin E, Leslie K, Fukata Y, Watanabe M, Fukata M, Meijer D. Development. 2014 Apr;141(8):1749-56.
Sleep tight, wake up bright. Should sleep deprivation be included as a potential risk factor for SUDEP?
Scorza FA, Duncan S, Cavalheiro EA, Scorza CA, Tufik S, Andersen ML. Epilepsy Behav. 2014 Apr; 33:75-6.
Control of synaptic vesicle endocytosis by an extracellular signalling molecule.
Smillie KJ, Pawson J, Perkins EM, Jackson M, Cousin MA.
Determinants of adult functional outcome in adolescents receiving special educational assistance.
McGeown HR, Johnstone EC, McKirdy J, Owens DC, Stanfield AC.
Early death in those previously hospitalised for mental healthcare in Scotland: a nationwide cohort study, 1986-2010.
Ajetunmobi O, Taylor M, Stockton D, Wood R.
Epilepsy health consumer groups and charities; how representative of patients are they? The results of a pilot study.
Grinton M, Leavy Y, Ahern D, Hughes F, Duncan S.
Feedback inhibition enables θ-nested γ oscillations and grid firing fields.
Pastoll H, Solanka L, van Rossum MC, Nolan MF.
From 'implications' to 'dimensions': science, medicine and ethics in society.
Pickersgill MD.
HCN1 channels in cerebellar Purkinje cells promote late stages of learning and constrain synaptic inhibition.
Rinaldi A, Defterali C, Mialot A, Garden DL, Beraneck M, Nolan MF.
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.
Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE.J
In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy
Jennifer Doig , Lowri A Griffiths, David Peberdy, Permphan Dharmasaroja, Maria Vera, Faith J C Davies, Helen J Newbery, David Brownstein, Catherine M Abbott
Longitudinal gray matter change in young people who are at enhanced risk of schizophrenia due to intellectual impairment.
Moorhead TW, Stanfield AC, McKechanie AG, Dauvermann MR, Johnstone EC, Lawrie SM, Cunningham Owens DG.
Mapping the new molecular landscape: social dimensions of epigenetics.
Pickersgill M, Niewöhner J, Müller R, Martin P, Cunningham-Burley S.
Mild traumatic brain injury and epilepsy: alcohol misuse may underpin the association.
Welch KA, Derry C.J
Moving from a universal to targeted child health programme: which children receive enhanced care? A population-based study using routinely available data.
Wood R, Stockton D, Brown H.
Munc18-1 protein molecules move between membrane molecular depots distinct from vesicle docking sites.
Smyth AM, Yang L, Martin KJ, Hamilton C, Lu W, Cousin MA, Rickman C, Duncan RR.J
Prolonged febrile seizures cause reversible reductions in white matter integrity.
Yoong M, Seunarine K, Martinos M, Chin RF, Clark CA, Scott RC.
Quality of life in a cohort of men with epilepsy compared to a healthy population and those with common chronic diseases in the UK using a generic patient-reported outcome measure.
Greenway L, Ahern D, Leavy Y, Rawnsley M, Duncan S.
Sleep and epilepsy.
Derry CP, Duncan S.
Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin.
Cheung G, Cousin MA.
The social life of the brain: Neuroscience in society.
Pickersgill MD.
The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.
Gordon SL, Cousin MA.
Trends in emergency hospital admissions of children: observations from Scotland.
Wood R, Blair M, Wilson P.
Visual field defects after radiosurgery for mesial temporal lobe epilepsy.
Piper RJ, Yoong M, McLellan A, Kandasamy J, Chin RF.
X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval.
Gordon SL, Cousin MA.
Lack of efficacy of phenytoin in children presenting with febrile status epilepticus.
Pujar SS, Scott RC, Chin RF. Am J Emerg Med. 2012 Nov;30(9):2073-4.
Retrospective study of sensitivity and specificity of EEG in the elderly compared with younger age groups.
Watson P, Conroy A, Moran G, Duncan S. Epilepsy Behav. 2012 Nov;25(3):408-11.
Nocturnal Frontal Lobe Epilepsy vs Parasomnias.
Derry C. Curr Treat Options Neurol. 2012 Oct; 14(5):451-63.
Recognition memory is impaired in children after prolonged febrile seizures.
Martinos MM, Yoong M, Patil S, Chin RF, Neville BG, Scott RC, de Haan M. Brain. 2012 Oct; 135(Pt 10):3153-64.
Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling.
Akam T, Oren I, Mantoan L, Ferenczi E, Kullmann DM. May 2012; Nature Neurosci. 15:763-8.
The role of magnetic resonance imaging in the follow-up of children with convulsive status epilepticus.
Yoong M, Madari R, Martinos M, Clark C, Chong K, Neville B, Chin R, Scott R. Dev Med Child Neurol. 2012 Apr; 54(4):328-33.
Autoimmune limbic encephalitis.
Derry CP, Wilkie MD, Al-Shahi Salman R, Davenport RJ. Clin Med. 2011 Oct;11(5):476-8.
Death within 8 years after childhood convulsive status epilepticus: a population-based study.
Pujar SS, Neville BG, Scott RC, Chin RF; North London Epilepsy Research Network. Brain. 2011 Oct; 134(Pt 10):2819-27.
Neuroendocrinological aspects of epilepsy: important issues and trends in future research.
Pack AM, Reddy DS, Duncan S, Herzog A. Epilepsy Behav. 2011 Sep;22(1):94-102.
Outcomes of childhood epilepsy at age 33 years: a population-based birth-cohort study.
Chin RF, Cumberland PM, Pujar SS, Peckham C, Ross EM, Scott RC. Epilepsia. 2011 Aug; 52(8):1513-21.
Sudden unexpected death in epilepsy.
Duncan S, Brodie MJ. Epilepsy Behav. 2011 Aug; 21(4):344-51.
The sleep manifestations of frontal lobe epilepsy.
Derry CP. Curr Neurol Neurosci Rep. 2011 Apr;11(2):218-26.
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